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IL22RA2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9209354

The protein encoded by this gene is a soluble class IIcytokine receptor. This protein has been shown to specifically bindto interleukin 22 (IL22), block the interaction of IL22 with itscell surface receptor, and thus inhibit IL22 activity. This… More details

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Product Overview

Online Datasheet in PDF
Product Name
IL22RA2, Polyclonal Antibody
Full Product Name
IL22RA2 Antibody (N-term)
Product Gene Name
Product Synonym Names
Interleukin-22 receptor subunit alpha-2; IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; Cytokine receptor class-II member 10; Cytokine receptor family 2 member 10; CRF2-10; Cytokine receptor family type 2; soluble 1; CRF2-S1; Interleukin-22-binding protein; IL-22BP; IL22BP; ZcytoR16; IL22RA2
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 0.5 (lot specific)
Specificity
This IL22RA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-42 amino acids from the N-terminal region of human IL22RA2.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
IL22RA2 peptide (MBS9223573) is used for blocking the activity of IL22RA2 antibody (MBS9209354)
Molecular Weight
30550
Immunogen Sequence Positions
15-42
OMIM
606648
3D Structure
ModBase 3D Structure for Q969J5
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN

Product Categories/Family for anti-IL22RA2 antibody

Applications Tested/Suitable for anti-IL22RA2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-IL22RA2 antibody
WB~~1:1000

Western Blot (WB) of anti-IL22RA2 antibody

IL22RA2 Antibody (N-term) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the IL22RA2 antibody detected the IL22RA2 protein (arrow).
Rabbit Anti-IL22RA2 Polyclonal Antibody – Cat# MBS9209354

Product References and Citations for anti-IL22RA2 antibody

Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Kingo, K., et al. J. Dermatol. Sci. 57(1):71-73(2010)
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Endam, L.M., et al. Otolaryngol Head Neck Surg 140(5):741-747(2009)
de Moura, P.R., et al. FEBS Lett. 583(7):1072-1077(2009)

Other Notes

Small volumes of anti-IL22RA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL22RA2 purchase

MBS9209354 is an antibody targeting IL22RA2. Also known as IL22RA2 Antibody (N-term). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL22RA2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
interleukin-22 receptor subunit alpha-2 isoform 1
NCBI Official Synonym Full Names
interleukin 22 receptor, alpha 2
NCBI Official Symbol
IL22RA2
NCBI Official Synonym Symbols
CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2; ZCYTOR16; IL-22R-alpha-2
UniProt Protein Name
Interleukin-22 receptor subunit alpha-2
UniProt Synonym Protein Names
Cytokine receptor class-II member 10; Cytokine receptor family 2 member 10; CRF2-10; Cytokine receptor family type 2, soluble 1; CRF2-S1; Interleukin-22-binding protein; IL-22BP; IL22BP; ZcytoR16
UniProt Gene Name
IL22RA2
UniProt Synonym Gene Names
IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; CRF2-10; CRF2-S1; IL-22BP; IL22BP
UniProt Entry Name
I22R2_HUMAN
NCBI Protein Information
interleukin-22 receptor subunit alpha-2

NCBI Summary for IL22RA2

This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
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UniProt Comments for IL22RA2

IL22RA2: Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Belongs to the type II cytokine receptor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: extracellular space; integral to membrane; plasma membrane; cytosol

Molecular Function: interleukin-22 binding; interleukin-22 receptor activity

Biological Process: regulation of tyrosine phosphorylation of Stat3 protein; cytokine and chemokine mediated signaling pathway; negative regulation of inflammatory response
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-IL22RA2 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with IL22RA2 and Lung
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