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ILKAP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647697

The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the… More details

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Product Overview

Online Datasheet in PDF
Product Name
ILKAP, Polyclonal Antibody
Full Product Name
ILKAP, ID (ILKAP, Integrin-linked kinase-associated serine/threonine phosphatase 2C)
Product Gene Name
anti-ILKAP antibody
Product Synonym Names
Anti -ILKAP, ID (ILKAP, Integrin-linked kinase-associated serine/threonine phosphatase 2C)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
42,907 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (239079043..239112343, complement). Location: 2q37.3
3D Structure
ModBase 3D Structure for Q9H0C8
Immunogen
ILKAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-122 amino acids from the Central region of human ILKAP.

Product Categories/Family for anti-ILKAP antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-ILKAP antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ILKAP antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Western Blot (WB) of anti-ILKAP antibody

ILKAP Antibody (Center) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the ILKAP antibody detected the ILKAP protein (arrow).
Rabbit Anti-ILKAP Polyclonal Antibody – Cat# MBS647697

Other Notes

Small volumes of anti-ILKAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ILKAP purchase

MBS647697 is an antibody targeting ILKAP. Also known as ILKAP, ID (ILKAP, Integrin-linked kinase-associated serine/threonine phosphatase 2C). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ILKAP. It may not necessarily be applicable to this product.

NCBI GI #
13540531
NCBI GeneID
80895
NCBI Accession #
NP_110395.1
UniProt Primary Accession #
Q9H0C8
UniProt Secondary Accession #
B3KM39
UniProt Related Accession #
Q9H0C8
GenBank Nucleotide #
NM_030768.2
NCBI Official Full Name
integrin-linked kinase-associated serine/threonine phosphatase 2C
NCBI Official Synonym Full Names
integrin-linked kinase-associated serine/threonine phosphatase
NCBI Official Symbol
ILKAP
NCBI Official Synonym Symbols
ILKAP2; ILKAP3; PP2C-DELTA
UniProt Protein Name
Integrin-linked kinase-associated serine/threonine phosphatase 2C
Protein Family
Integrin-linked kinase-associated serine/threonine phosphatase
UniProt Gene Name
ILKAP
UniProt Synonym Gene Names
ILKAP
UniProt Entry Name
ILKAP_HUMAN
NCBI Protein Information
integrin-linked kinase-associated serine/threonine phosphatase 2C; protein phosphatase 2c, delta isozyme; integrin-linked kinase associated phosphatase

UniProt Comments for ILKAP

Function: Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation. Ref.1 Ref.7

Catalytic activity: A phosphoprotein + H2O = a protein + phosphate.

Cofactor: Binds 2 magnesium or manganese ions per subunit

By similarity. Ref.1

Enzyme regulation: Inhibited rather than stimulated by magnesium.

Subunit structure: Interacts with ILK. Specific association with ILK is independent of the catalytic activity of either partner. Ref.1 Ref.7

Subcellular location: Cytoplasm Ref.1.

Tissue specificity: Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues. Ref.1

Sequence similarities: Belongs to the PP2C family.Contains 1 PP2C-like domain.
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Research Articles on ILKAP

1. ILKAP is a nuclear protein that regulates cell survival and apoptosis through the regulation of RSK2 signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ILKAP antibody

 Reference Product  PubMed Publications
 ILK antibody  >4 publications with ILKAP and ILK

Diseases associated with anti-ILKAP antibody

 Disease Name  Pubmed Publications
 Ataxia Antibodies  >1 publications with ILKAP and Ataxia
 Nervous System Diseases Antibodies  >1 publications with ILKAP and Nervous System Diseases

Organs/Tissues associated with anti-ILKAP antibody

 Organ/Tissue Name  Pubmed Publications
 Mouth Antibodies  >2 publications with ILKAP and Mouth
 Blood Antibodies  >2 publications with ILKAP and Blood
 Prostate Antibodies  >1 publications with ILKAP and Prostate
 Kidney Antibodies  >1 publications with ILKAP and Kidney
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