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IMPACT Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7004009

Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein… More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IMPACT, Polyclonal Antibody
Full Product Name
IMPACT Antibody
Product Gene Name
anti-IMPACT antibody
Product Synonym Names
Protein IMPACT; Imprinted and ancient gene protein homolog; IMPACT
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
>95%,Protein G purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
Matching Pairs
Unconjugated Antibody: IMPACT (MBS7004009)
FITC Conjugated Antibody: IMPACT (MBS7002168)
Matching Pairs
Unconjugated Antibody: IMPACT (MBS7004009)
Biotin Conjugated Antibody: IMPACT (MBS7002348)
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Molecular Weight
22,999 Da
OMIM
615319
3D Structure
ModBase 3D Structure for Q9P2X3
Immunogen
Recombinant human Protein IMPACT protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-IMPACT antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-IMPACT antibody

Western blot
All lanes: IMPACT antibody at 10 ug/ml
Lane 1: Hela whole cell lysate
Lane 2: HL60 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 37,23 kDa
Observed band size: 36,52 kDa
Rabbit Anti-IMPACT Polyclonal Antibody – Cat# MBS7004009

Immunohistochemistry (IHC) of anti-IMPACT antibody

Immunohistochemistry of paraffin-embedded human endometrial cancer using MBS7004009 at dilution of 1:100
Rabbit Anti-IMPACT Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS7004009

Immunohistochemistry (IHC) of anti-IMPACT antibody

Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7004009 at dilution of 1:100
Rabbit Anti-IMPACT Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS7004009

Other Notes

Small volumes of anti-IMPACT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IMPACT purchase

MBS7004009 is an antibody targeting IMPACT. Also known as IMPACT Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IMPACT. It may not necessarily be applicable to this product.

NCBI GI #
8923819
NCBI GeneID
55364
NCBI Accession #
NP_060909.1
UniProt Primary Accession #
Q9P2X3
UniProt Secondary Accession #
Q49AM0; Q9H2X4; A8MXG0
UniProt Related Accession #
Q9P2X3
GenBank Nucleotide #
NM_018439.3
NCBI Official Full Name
protein IMPACT
NCBI Official Synonym Full Names
impact RWD domain protein
NCBI Official Symbol
IMPACT
NCBI Official Synonym Symbols
RWDD5
UniProt Protein Name
Protein IMPACT
UniProt Synonym Protein Names
Imprinted and ancient gene protein homolog
Protein Family
Protein
UniProt Gene Name
IMPACT
UniProt Entry Name
IMPCT_HUMAN
NCBI Protein Information
protein IMPACT

UniProt Comments for IMPACT

IMPACT: Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. Belongs to the IMPACT family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 18q11.2-q12.1

Cellular Component: cytoplasm; polysome

Biological Process: cellular response to amino acid starvation; cellular response to glucose starvation; negative regulation of protein amino acid autophosphorylation; negative regulation of protein amino acid phosphorylation; negative regulation of protein complex assembly; negative regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation
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Research Articles on IMPACT

1. Data suggest that high expression of protein IMPACT homolog in non-immune cells acts as a protective mechanism against indoleamine 2,3-dioxygenase (IDO)-induced GCN2 activation, making them resistant to the amino acid-deprived environment caused by IDO.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IMPACT antibody

 Reference Product  PubMed Publications
 LARGE antibody  >47802 publications with IMPACT and LARGE
 UBC antibody  >804 publications with IMPACT and UBC
 KCNE1 antibody  >21 publications with IMPACT and KCNE1
 HAS1 antibody  >11 publications with IMPACT and HAS1
 MAN2C1 antibody  >1 publications with IMPACT and MAN2C1
 SGCG antibody  >1 publications with IMPACT and SGCG
 GCN1L1 antibody  >1 publications with IMPACT and GCN1L1
 COPS5 antibody  >1 publications with IMPACT and COPS5

Diseases associated with anti-IMPACT antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >29028 publications with IMPACT and Heart Diseases
 Inflammation Antibodies  >16683 publications with IMPACT and Inflammation
 Hypertension Antibodies  >14032 publications with IMPACT and Hypertension
 Liver Diseases Antibodies  >11622 publications with IMPACT and Liver Diseases
 Kidney Diseases Antibodies  >11535 publications with IMPACT and Kidney Diseases
 Neoplasm Metastasis Antibodies  >6946 publications with IMPACT and Neoplasm Metastasis
 Necrosis Antibodies  >6822 publications with IMPACT and Necrosis
 Lung Neoplasms Antibodies  >6422 publications with IMPACT and Lung Neoplasms
 Hemorrhage Antibodies  >6379 publications with IMPACT and Hemorrhage
 Prostatic Diseases Antibodies  >5669 publications with IMPACT and Prostatic Diseases

Organs/Tissues associated with anti-IMPACT antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >36104 publications with IMPACT and Brain
 Heart Antibodies  >34672 publications with IMPACT and Heart
 Vascular Antibodies  >23905 publications with IMPACT and Vascular
 Bone Antibodies  >21746 publications with IMPACT and Bone
 Lung Antibodies  >19276 publications with IMPACT and Lung
 Liver Antibodies  >19209 publications with IMPACT and Liver
 Kidney Antibodies  >17845 publications with IMPACT and Kidney
 Muscle Antibodies  >16516 publications with IMPACT and Muscle
 Skin Antibodies  >11350 publications with IMPACT and Skin
 Eye Antibodies  >7695 publications with IMPACT and Eye
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