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INPP5B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6310589

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases).… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
INPP5B, Polyclonal Antibody
Full Product Name
INPP5B, CT (INPP5B, OCRL2, Type II inositol 1,4,5-trisphosphate 5-phosphatase, 75kD inositol polyphosphate-5-phosphatase, Phosphoinositide 5-phosphatase) (FITC)
Product Gene Name
anti-INPP5B antibody
Product Synonym Names
INPP5B; OCRL2; Type II inositol 1,4,5-trisphosphate 5-phosphatase; 75kD inositol polyphosphate-5-phosphatase; Phosphoinositide 5-phosphatase
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
993
Chromosome Location
Chromosome: 1; NC_000001.10 (38326369..38412729, complement). Location: 1p34
OMIM
147264
3D Structure
ModBase 3D Structure for P32019
Immunogen
INPP5B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 957-987 amino acids from the C-terminal region of human INPP5B.
Conjugate
FITC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-INPP5B antibody

Antibodies; Enzymes; Phosphatase
Applications Tested/Suitable for anti-INPP5B antibody
Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-INPP5B antibody
FC/FACS: 1:10-50
FLISA: 1:1,000
IHC: 1:50-100
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-INPP5B antibody

INPP5B Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the INPP5B antibody detected the INPP5B protein (arrow).
Rabbit Anti-INPP5B Polyclonal Antibody – Cat# MBS6310589

Immunohistochemistry (IHC) of anti-INPP5B antibody

INPP5B antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of the INPP5B antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-INPP5B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6310589

Flow Cytometry (FC/FACS) of anti-INPP5B antibody

INPP5B Antibody (C-term) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-INPP5B Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6310589

Product References and Citations for anti-INPP5B antibody

Coon, B.G., et al. Hum. Mol. Genet. 18(23):4478-4491(2009). Mao, Y., et al. EMBO J. 28(13):1831-1842(2009). Williams, C., et al. J. Cell. Sci. 120 (PT 22), 3941-3951 (2007): Speed, C.J., et al. Eur. J. Biochem. 234(1):216-224(1995) Janne, P.A., et al. Genomics 28(2):280-285(1995).

Other Notes

Small volumes of anti-INPP5B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for INPP5B purchase

MBS6310589 is an antibody targeting INPP5B. Also known as INPP5B, CT (INPP5B, OCRL2, Type II inositol 1,4,5-trisphosphate 5-phosphatase, 75kD inositol polyphosphate-5-phosphatase, Phosphoinositide 5-phosphatase) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for INPP5B. It may not necessarily be applicable to this product.

NCBI GI #
113722125
NCBI GeneID
3633
NCBI Accession #
NP_005531.2
UniProt Primary Accession #
P32019
UniProt Secondary Accession #
Q5VSG9; Q5VSH0; Q5VSH1; Q658Q5; Q6P6D4; Q6PD53; Q86YE1; C9J6U5
UniProt Related Accession #
P32019
GenBank Nucleotide #
NM_005540.2
NCBI Official Full Name
type II inositol 1,4,5-trisphosphate 5-phosphatase
NCBI Official Synonym Full Names
inositol polyphosphate-5-phosphatase, 75kDa
NCBI Official Symbol
INPP5B
NCBI Official Synonym Symbols
5PTase
UniProt Protein Name
Type II inositol 1,4,5-trisphosphate 5-phosphatase
UniProt Synonym Protein Names
75 kDa inositol polyphosphate-5-phosphatase; Phosphoinositide 5-phosphatase
Protein Family
Type II inositol 1,4,5-trisphosphate 5-phosphatase
UniProt Gene Name
INPP5B
UniProt Synonym Gene Names
OCRL2; 5PTase
UniProt Entry Name
I5P2_HUMAN
NCBI Protein Information
type II inositol 1,4,5-trisphosphate 5-phosphatase; phosphoinositide 5-phosphatase; 75 kDa inositol polyphosphate-5-phosphatase; type II inositol-1,4,5-trisphosphate 5-phosphatase

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-INPP5B antibody

 Products by Pathway  Pathway Diagram
 1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies  1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram
 1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies  1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram
 3-phosphoinositide Degradation Pathway antibodies  3-phosphoinositide Degradation Pathway Diagram
 3-phosphoinositide Degradation Pathway antibodies  3-phosphoinositide Degradation Pathway Diagram
 D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram

Diseases associated with anti-INPP5B antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with INPP5B and Nervous System Diseases
 Infertility, Male Antibodies  >2 publications with INPP5B and Infertility, Male
 Infertility, Female Antibodies  >2 publications with INPP5B and Infertility, Female
 Genital Diseases, Male Antibodies  >1 publications with INPP5B and Genital Diseases, Male
 Weight Loss Antibodies  >1 publications with INPP5B and Weight Loss

Organs/Tissues associated with anti-INPP5B antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with INPP5B and Eye
 Kidney Antibodies  >1 publications with INPP5B and Kidney
 Embryonic Tissue Antibodies  >1 publications with INPP5B and Embryonic Tissue
 Testis Antibodies  >1 publications with INPP5B and Testis
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