Integrin Alpha V (ITGaV) Antibody – Rabbit Polyclonal

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

ITGAV: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Belongs to the integrin alpha chain family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q32.1

Cellular Component: cell surface; filopodium membrane; focal adhesion; integrin complex; membrane; microvillus membrane; phagocytic vesicle; plasma membrane

Molecular Function: C-X3-C chemokine binding; coreceptor activity; extracellular matrix binding; fibroblast growth factor binding; fibronectin binding; insulin-like growth factor I binding; opsonin binding; protease binding; protein binding; protein kinase C binding; transforming growth factor beta binding; voltage-gated calcium channel activity

Biological Process: angiogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell adhesion; cell adhesion mediated by integrin; cell growth; cell migration; cell-matrix adhesion; cell-substrate adhesion; entry of virus into host cell; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; leukocyte migration; negative chemotaxis; negative regulation of lipid transport; negative regulation of lipoprotein metabolic process; negative regulation of low-density lipoprotein receptor biosynthetic process; positive regulation of cell adhesion; positive regulation of cell proliferation; regulation of phagocytosis; vascular endothelial growth factor receptor signaling pathway