Interleukin-4 (IL4) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

IL4: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Belongs to the IL-4/IL-13 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; Cytokine; Cell cycle regulation

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: external side of plasma membrane; extracellular space

Molecular Function: cytokine activity; growth factor activity; interleukin-4 receptor binding; protein binding

Biological Process: B cell costimulation; B cell differentiation; cellular defense response; chemotaxis; cholesterol metabolic process; connective tissue growth factor biosynthetic process; defense response to protozoan; female pregnancy; immune response; innate immune response in mucosa; microglial cell activation; myeloid dendritic cell differentiation; negative regulation of acute inflammatory response; negative regulation of apoptosis; negative regulation of chronic inflammatory response; negative regulation of macrophage activation; negative regulation of nitric oxide biosynthetic process; negative regulation of osteoclast differentiation; negative regulation of transcription, DNA-dependent; positive regulation of activated T cell proliferation; positive regulation of B cell proliferation; positive regulation of chemokine biosynthetic process; positive regulation of defense response to virus by host; positive regulation of interleukin-10 production; positive regulation of interleukin-13 production; positive regulation of isotype switching to IgE isotypes; positive regulation of isotype switching to IgG isotypes; positive regulation of mast cell degranulation; positive regulation of MHC class II biosynthetic process; positive regulation of T cell differentiation; positive regulation of T cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of immune response; regulation of isotype switching; regulation of phosphorylation; regulation of proton transport; response to cytokine stimulus; response to drug; response to ethanol; response to nutrient; response to organic cyclic substance; retina development in camera-type eye; T-helper 1 cell lineage commitment; T-helper 2 cell differentiation; T-helper 2 type immune response

Disease: Stroke, Ischemic