Rabbit Anti-IREB2 Polyclonal Antibody – Cat# MBS6310877

IREB2 Antibody – Rabbit Polyclonal

Name: IREB2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6310877
Price: 1025 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6310877

IREB2 is a RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE… More details

$1025 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IREB2, Polyclonal Antibody

Full Product Name

IREB2, ID (IREB2, Iron-responsive element-binding protein 2, Iron regulatory protein 2) (MaxLight 405)

Product Gene Name

anti-IREB2 antibody

Product Synonym Names

IREB2; Iron-responsive element-binding protein 2; Iron regulatory protein 2

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

37,487 Da

OMIM

147582

3D Structure

ModBase 3D Structure for P48200

Immunogen

IREB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-238 amino acids from the Central region of human IREB2.

Conjugate

MaxLight405

Note

Preservative Free

Product Categories/Family for anti-IREB2 antibody

Antibodies; Binding Proteins

Applications Tested/Suitable for anti-IREB2 antibody

Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB)

Application Notes for anti-IREB2 antibody

FC/FACS: 1:10-50
FLISA: 1:1,000
IHC: 1:10-50
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-IREB2 antibody

Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010). Hansen, H.M., et al. Hum. Mol. Genet. 19(18):3652-3661(2010). Cho, M.H., et al. Nat. Genet. 42(3):200-202(2010). Salahudeen, A.A., et al. Science 326(5953):722-726(2009). DeMeo, D.L., et al. Am. J. Hum. Genet. 85(4):493-502(2009).

Other Notes

Small volumes of anti-IREB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IREB2 purchase

MBS6310877 is an antibody targeting IREB2. Also known as IREB2, ID (IREB2, Iron-responsive element-binding protein 2, Iron regulatory protein 2) (MaxLight 405). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IREB2. It may not necessarily be applicable to this product.

NCBI GI #

41352693

NCBI GeneID

3658

NCBI Accession #

NP_004127.1

UniProt Primary Accession #

P48200

UniProt Secondary Accession #

Q13095; Q1HE21; Q59FQ7; Q8WVK6; Q9UF17; A8KAC7; E1CJT9; H0YKU0

UniProt Related Accession #

P48200

GenBank Nucleotide #

NM_004136.2

NCBI Official Full Name

iron-responsive element-binding protein 2

NCBI Official Synonym Full Names

iron-responsive element binding protein 2

NCBI Official Symbol

IREB2

NCBI Official Synonym Symbols

ACO3; IRP2; IRP2AD

UniProt Protein Name

Iron-responsive element-binding protein 2

UniProt Synonym Protein Names

Iron regulatory protein 2; IRP2

Protein Family

Iron-responsive element-binding protein

UniProt Gene Name

IREB2

UniProt Synonym Gene Names

IRE-BP 2; IRP2

UniProt Entry Name

IREB2_HUMAN

NCBI Protein Information

iron-responsive element-binding protein 2; IRE-BP 2; iron regulatory protein 2

UniProt Comments for IREB2

IREB2: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'- UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. Belongs to the aconitase/IPM isomerase family.

Protein type: RNA-binding; Translation

Chromosomal Location of Human Ortholog: 15q25.1

Cellular Component: mitochondrion; cytoplasm; cytosol

Molecular Function: protein binding; iron-responsive element binding; translation repressor activity; RNA binding; metal ion binding; 4 iron, 4 sulfur cluster binding

Biological Process: erythrocyte homeostasis; response to retinoic acid; cellular iron ion homeostasis; negative regulation of translation; response to iron(II) ion; osteoclast differentiation; iron ion transport; protoporphyrinogen IX biosynthetic process; intestinal absorption; aging; post-embryonic development

Research Articles on IREB2

1. IRE2 is located within genes previously associated with chronic obstructive pulmonary disease susceptibility.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IREB2 antibody

Reference Product	PubMed Publications
AGPHD1 antibody	>2 publications with IREB2 and AGPHD1
MAX antibody	>1 publications with IREB2 and MAX

Pathways associated with anti-IREB2 antibody

Products by Pathway	Pathway Diagram
Iron Metabolism In Placenta Pathway antibodies	Iron Metabolism In Placenta Pathway Diagram
Validated Targets Of C-MYC Transcriptional Activation Pathway antibodies	Validated Targets Of C-MYC Transcriptional Activation Pathway Diagram

Diseases associated with anti-IREB2 antibody

Disease Name	Pubmed Publications
Lung Neoplasms Antibodies	>4 publications with IREB2 and Lung Neoplasms
Brain Diseases Antibodies	>4 publications with IREB2 and Brain Diseases
Anemia Antibodies	>2 publications with IREB2 and Anemia
Hypertension Antibodies	>1 publications with IREB2 and Hypertension
Liver Diseases Antibodies	>1 publications with IREB2 and Liver Diseases

Organs/Tissues associated with anti-IREB2 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>12 publications with IREB2 and Lung
Brain Antibodies	>6 publications with IREB2 and Brain
Muscle Antibodies	>1 publications with IREB2 and Muscle
Blood Antibodies	>1 publications with IREB2 and Blood
Intestine Antibodies	>1 publications with IREB2 and Intestine
Vascular Antibodies	>1 publications with IREB2 and Vascular