IRS2 Antibody – Rabbit Polyclonal

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]

IRS2: May mediate the control of various cellular processes by insulin. Interacts with PHIP.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: plasma membrane; cytosol

Molecular Function: protein domain specific binding; signal transducer activity; protein binding; phosphoinositide 3-kinase binding; protein kinase binding; protein phosphatase binding; insulin receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of kinase activity; regulation of lipid metabolic process; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of glycogen biosynthetic process; lipid homeostasis; positive regulation of insulin secretion; glucose metabolic process; signal transduction; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; cell proliferation; mammary gland development; cellular response to insulin stimulus; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of B cell proliferation; response to glucose stimulus; insulin receptor signaling pathway; innate immune response; brain development; negative regulation of B cell apoptosis; positive regulation of cell migration

Disease: Diabetes Mellitus, Noninsulin-dependent