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AIMP2 Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6008247

JTV1 is probable core protein of the multisynthetase complex that serves as a template for the assembly of the supramolecular structure. This protein Mediates ubiquitination of FUBP1 and its degradation by the proteasome. More details

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Product Overview

Online Datasheet in PDF
Product Name
JTV1 (AIMP2), Polyclonal Antibody
Full Product Name
JTV1 (Aminoacyl tRNA Synthase Complex-interacting Multifunctional Protein 2, Multisynthetase Complex Auxiliary Component p38, Protein JTV-1, PRO0992)
Product Gene Name
Product Synonym Names
Anti -JTV1 (Aminoacyl tRNA Synthase Complex-interacting Multifunctional Protein 2, Multisynthetase Complex Auxiliary Component p38, Protein JTV-1, PRO0992)
Immunogen Sequence
MPMYQVKPYH GGGAPLRVEL PTCMYRLPNV HGRSYGPAPG AGHVQEESNL SLQALESRQD DILKRLYELK AAVDGLSKMI QTPDADLDVT NIIQADEPTT LTTNALDLNS VLGKDYGALK DIVINANPAS PPLSLLVLHR LLCEHFRVLS TVHTHSSVKS VPENLLKCFG EQNKKQPRQD YQLGFTLIWK NVPKTQMKFS IQTMCPIEGE GNIARFLFSL FGQKHNAVNA TLIDSWVDIA IFQLKEGSSK EKAAVFRSMN SALGKSPWLA GNELTVADVV LWSVLQQIGG CSVTVPANVQ RWMRSCENLA PFNTALKLLK
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human JTV1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
35,349 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (6048882..6063465). Location: 7p22
OMIM
600859
3D Structure
ModBase 3D Structure for Q13155
Immunogen
Full length human JTV1, aa1-320 (NP_006294.2).

Product Categories/Family for anti-AIMP2 antibody

Applications Tested/Suitable for anti-AIMP2 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-AIMP2 antibody
Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

Western Blot (WB) of anti-AIMP2 antibody

Western Blot analysis of JTV1 expression in transfected 293T cell line by JTV1 polyclonal antibody. Lane 1: JTV1 transfected lysate (35.2kD). Lane 2: Non-transfected lysate.
Mouse Anti-AIMP2 Polyclonal Antibody – Cat# MBS6008247

Immunofluorescence (IF) of anti-AIMP2 antibody

Immunofluorescence of purified antibody to JTV1 on HeLa cell. [antibody concentration 10ug/ml]
Mouse Anti-AIMP2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS6008247

Other Notes

Small volumes of anti-AIMP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AIMP2 purchase

MBS6008247 is an antibody targeting AIMP2. Also known as JTV1 (Aminoacyl tRNA Synthase Complex-interacting Multifunctional Protein 2, Multisynthetase Complex Auxiliary Component p38, Protein JTV-1, PRO0992). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for AIMP2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
JTV1 gene, isoform CRA_a
NCBI Official Synonym Full Names
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
NCBI Official Symbol
AIMP2
NCBI Official Synonym Symbols
P38; JTV1; JTV-1; PRO0992
UniProt Protein Name
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
UniProt Synonym Protein Names
Multisynthase complex auxiliary component p38; Protein JTV-1
UniProt Gene Name
AIMP2
UniProt Synonym Gene Names
JTV1
UniProt Entry Name
AIMP2_HUMAN
NCBI Protein Information
aminoacyl tRNA synthase complex-interacting multifunctional protein 2; protein JTV-1; ARS-interacting multi-functional protein 2; multisynthase complex auxiliary component p38; multisynthetase complex auxiliary component p38

NCBI Summary for AIMP2

The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown. [provided by RefSeq, Jul 2008]
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UniProt Comments for AIMP2

JTV1: Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: membrane; nucleus; cytosol

Molecular Function: protein binding

Biological Process: negative regulation of cell proliferation; tRNA aminoacylation for protein translation; apoptosis; positive regulation of protein ubiquitination; gene expression
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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