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JUNB Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6383391

The JunB transcription factor, also known as JunB proto-oncogene, JunB oncogene, transcription factor JunB, and transforming protein JunB, is a basic region leucine zipper DNA-binding protein, and a member of the Jun family of proteins, which also includes… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
JUNB, Polyclonal Antibody
Full Product Name
JUNB (Transcription Factor Jun-B) (FITC)
Product Gene Name
anti-JUNB antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human JUNB.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
35,879 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (12902310..12904125). Location: 19p13.2
OMIM
165161
3D Structure
ModBase 3D Structure for P17275
Immunogen
Full length human JUNB, aa1-347 (NP_002220.1).
Immunogen Sequence
MCTKMEQPFYHDDSYTATGYGRAPGGLSLHDYKLLKPSLAVNLADPYRSLKAPGARGPGPEGGGGGSYFSGQGSDTGASLKLASSELERLIVPNSNGVITTTPTPPGQYFYPRGGGSGGGAGGAGGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSLGATGGPPAGPGGVYAGPEPPPVYTNLSSYSPASASSGGAGAAVGTGSSYPTTTISYLPHAPPFAGGHPAQLGLGRGASTFKEEPQTVPEARSRDATPPVSPINMEDQERIKVERKRLRNRLAATKCRKRKLERIARLEDKVKTLKAENAGLSSTAGLLREQVAQLKQKVMTHVSNGCQLLLGVKGHAF
Conjugate
FITC
Note
Preservative Free

Product Categories/Family for anti-JUNB antibody

Antibodies; Transcription Factors
Applications Tested/Suitable for anti-JUNB antibody
Western Blot (WB)
Application Notes for anti-JUNB antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-JUNB antibody

Western Blot analysis of JUNB expression in transfected 293T cell line by JUNB polyclonal antibody. Lane 1: JUNB transfected lysate (35.9kD). Lane 2: Non-transfected lysate.
Rabbit Anti-JUNB Polyclonal Antibody – Cat# MBS6383391

Other Notes

Small volumes of anti-JUNB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JUNB purchase

MBS6383391 is an antibody targeting JUNB. Also known as JUNB (Transcription Factor Jun-B) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for JUNB. It may not necessarily be applicable to this product.

NCBI GI #
4504809
NCBI GeneID
3726
NCBI Accession #
NP_002220.1
UniProt Primary Accession #
P17275
UniProt Secondary Accession #
Q96GH3
UniProt Related Accession #
P17275
GenBank Nucleotide #
NM_002229.2
NCBI Official Full Name
transcription factor jun-B
NCBI Official Synonym Full Names
jun B proto-oncogene
NCBI Official Symbol
JUNB
NCBI Official Synonym Symbols
AP-1
UniProt Protein Name
Transcription factor jun-B
Protein Family
Transcription factor
UniProt Gene Name
JUNB
UniProt Entry Name
JUNB_HUMAN
NCBI Protein Information
transcription factor jun-B; activator protein 1

UniProt Comments for JUNB

JunB: Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'. Binds DNA as an homodimer or as an heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains). By growth factors. Belongs to the bZIP family. Jun subfamily.

Protein type: Transcription factor; Motility/polarity/chemotaxis; Oncoprotein

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: nucleoplasm; chromatin

Molecular Function: protein binding; DNA binding; transcription coactivator activity; double-stranded DNA binding; transcription factor activity; transcription corepressor activity

Biological Process: response to drug; transcription initiation from RNA polymerase II promoter; response to peptide hormone stimulus; response to light stimulus; response to cAMP; transcription, DNA-dependent; regulation of cell cycle; embryonic process involved in female pregnancy; decidualization; osteoclast differentiation; cellular response to hormone stimulus; trophectodermal cell differentiation; regulation of transcription from RNA polymerase II promoter; osteoblast differentiation; osteoblast proliferation; response to mechanical stimulus; response to cytokine stimulus; transforming growth factor beta receptor signaling pathway; gene expression; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; vasculogenesis; response to progesterone stimulus; response to corticosterone stimulus
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Research Articles on JUNB

1. Study confirmed that JunB was upregulated in VHL-defective clear-cell renal-cell carcinoma (ccRCC) specimens by immunostaining. Short-hairpin RNA (shRNA)-mediated knockdown of JunB in 786-O and A498 VHL null ccRCC cells suppressed their invasiveness.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-JUNB antibody

 Reference Product  PubMed Publications
 JUN antibody  >1007 publications with JUNB and JUN
 FOS antibody  >690 publications with JUNB and FOS
 FOSB antibody  >196 publications with JUNB and FOSB
 FOSL2 antibody  >32 publications with JUNB and FOSL2
 SMAD3 antibody  >23 publications with JUNB and SMAD3
 SMAD4 antibody  >14 publications with JUNB and SMAD4
 MAPK8 antibody  >5 publications with JUNB and MAPK8
 FOSL1 antibody  >4 publications with JUNB and FOSL1
 BRCA1 antibody  >3 publications with JUNB and BRCA1
 NFE2L1 antibody  >2 publications with JUNB and NFE2L1

Pathways associated with anti-JUNB antibody

 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Oncostatin M Signaling Pathway antibodies  Oncostatin M Signaling Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram

Diseases associated with anti-JUNB antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >318 publications with JUNB and Neoplasms
 Inflammation Antibodies  >74 publications with JUNB and Inflammation
 Necrosis Antibodies  >64 publications with JUNB and Necrosis
 Nervous System Diseases Antibodies  >50 publications with JUNB and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >41 publications with JUNB and Cardiovascular Diseases
 Drug Toxicity Antibodies  >35 publications with JUNB and Drug Toxicity
 Brain Diseases Antibodies  >35 publications with JUNB and Brain Diseases
 Liver Diseases Antibodies  >34 publications with JUNB and Liver Diseases
 Liver Neoplasms Antibodies  >29 publications with JUNB and Liver Neoplasms
 Hypertrophy Antibodies  >24 publications with JUNB and Hypertrophy

Organs/Tissues associated with anti-JUNB antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >200 publications with JUNB and Blood
 Brain Antibodies  >176 publications with JUNB and Brain
 Bone Antibodies  >80 publications with JUNB and Bone
 Liver Antibodies  >75 publications with JUNB and Liver
 Skin Antibodies  >71 publications with JUNB and Skin
 Nerve Antibodies  >58 publications with JUNB and Nerve
 Lung Antibodies  >52 publications with JUNB and Lung
 Vascular Antibodies  >46 publications with JUNB and Vascular
 Bone Marrow Antibodies  >39 publications with JUNB and Bone Marrow
 Kidney Antibodies  >32 publications with JUNB and Kidney
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