Rabbit Anti-KCNS3 Polyclonal Antibody – Cat# MBS6312753

KCNS3 Antibody (N-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the KCNS3 antibody detected the KCNS3 protein (arrow).

KCNS3 Antibody – Rabbit Polyclonal

Name: KCNS3 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6312753
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6312753

MBS6312753 is an antibody targeting KCNS3. Also known as KCNS3, NT (KCNS3, Potassium voltage-gated channel subfamily S member 3, Delayed-rectifier K(+) channel alpha subunit 3, Voltage-gated potassium channel subunit Kv9.3) (AP). Reactive in Human. Host:… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

KCNS3, Polyclonal Antibody

Full Product Name

KCNS3, NT (KCNS3, Potassium voltage-gated channel subfamily S member 3, Delayed-rectifier K(+) channel alpha subunit 3, Voltage-gated potassium channel subunit Kv9.3) (AP)

Product Gene Name

anti-KCNS3 antibody

Product Synonym Names

KCNS3; Potassium voltage-gated channel subfamily S member 3; Delayed-rectifier K(+) channel alpha subunit 3; Voltage-gated potassium channel subunit Kv9.3

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

OMIM

AF043472 mRNA

3D Structure

ModBase 3D Structure for Q9BQ31

Immunogen

KCNS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KCNS3.

Conjugate

Note

Preservative Free

Product Categories/Family for anti-KCNS3 antibody

Antibodies; Ion Channel

Applications Tested/Suitable for anti-KCNS3 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-KCNS3 antibody

WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-KCNS3 antibody

Nyholt, D.R., et al. Hum. Mol. Genet. 17(21):3318-3331(2008). van Es, M.A., et al. Nat. Genet. 40(1):29-31(2008). Schymick, J.C., et al. Lancet Neurol 6(4):322-328(2007). Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005). Kerschensteiner, D., et al. Proc. Natl. Acad. Sci. U.S.A. 102(17):6160-6165(2005).

Other Notes

Small volumes of anti-KCNS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNS3. It may not necessarily be applicable to this product.

NCBI GI #

25952108

NCBI GeneID

3790

NCBI Accession #

NP_002243.3

UniProt Primary Accession #

Q9BQ31

UniProt Related Accession #

Q9BQ31

GenBank Nucleotide #

NP_002243.3

NCBI Official Full Name

potassium voltage-gated channel subfamily S member 3

NCBI Official Synonym Full Names

potassium voltage-gated channel modifier subfamily S member 3

NCBI Official Symbol

KCNS3

NCBI Official Synonym Symbols

KV9.3

UniProt Protein Name

Potassium voltage-gated channel subfamily S member 3

UniProt Synonym Protein Names

Delayed-rectifier K(+) channel alpha subunit 3; Voltage-gated potassium channel subunit Kv9.3

Protein Family

Potassium voltage-gated channel subfamily

UniProt Gene Name

KCNS3

NCBI Protein Information

potassium voltage-gated channel subfamily S member 3

NCBI Summary for KCNS3

Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

UniProt Comments for KCNS3

Kv9.3: Potassium channel subunit. Modulates channel activity and reduces the ion flow. Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2p24.2

Cellular Component: cytosol; Golgi apparatus; integral component of membrane; plasma membrane; voltage-gated potassium channel complex

Molecular Function: delayed rectifier potassium channel activity; potassium channel regulator activity

Biological Process: potassium ion transport; protein homooligomerization; regulation of insulin secretion; regulation of molecular function

Research Articles on KCNS3

1. By in situ hybridization, KCNS3 mRNA levels were 23% lower in schizophrenia subjects than in controls. At the cellular level, both KCNS3 mRNA-expressing neuron density and KCNS3 mRNA level per neuron were significantly lower.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.