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KDM2B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6484150

MBS6484150 is an antibody targeting KDM2B. Also known as KDM2B, CT (Lysine-specific Demethylase 2B, JmjC Domain-containing Histone Demethylation Protein 1B, [Histone-H3]-lysine-36 Demethylase 1B, F-box/LRR-repeat Protein 10, F-box and Leucine-rich Repeat… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
KDM2B, Polyclonal Antibody
Full Product Name
KDM2B, CT (Lysine-specific Demethylase 2B, JmjC Domain-containing Histone Demethylation Protein 1B, [Histone-H3]-lysine-36 Demethylase 1B, F-box/LRR-repeat Protein 10, F-box and Leucine-rich Repeat Protein 10, F-box Protein FBL10, Protein JEMMA, Jumonji D
Product Gene Name
anti-KDM2B antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human FBXL10b.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
63,630 Da
OMIM
609078
3D Structure
ModBase 3D Structure for Q8NHM5
Immunogen
Synthetic peptide selected from the C-terminal region of human FBXL10a and FBXL10b (KLH).
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-KDM2B antibody

Antibodies; Enzymes; Demethylase
Applications Tested/Suitable for anti-KDM2B antibody
Immunohistochemistry (IHC), FLISA
Application Notes for anti-KDM2B antibody
IHC: 1:10-1:50
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-KDM2B antibody

1. Jin, J., et al., Genes Dev. 18(21):2573-2580 (2004).

Other Notes

Small volumes of anti-KDM2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KDM2B. It may not necessarily be applicable to this product.

NCBI GI #
54112382
NCBI GeneID
84678
NCBI Accession #
NP_115979
UniProt Primary Accession #
Q8NHM5
UniProt Secondary Accession #
Q1RLM7; Q8NCI2; Q96HC7; Q96SL0; Q96T03; Q9NS96; Q9UF75; A8MRS1
UniProt Related Accession #
Q8NHM5
GenBank Nucleotide #
NM_032590
NCBI Official Full Name
lysine-specific demethylase 2B isoform a
NCBI Official Synonym Full Names
lysine (K)-specific demethylase 2B
NCBI Official Symbol
KDM2B
NCBI Official Synonym Symbols
CXXC2; Fbl10; PCCX2; FBXL10; JHDM1B
UniProt Protein Name
Lysine-specific demethylase 2B
UniProt Synonym Protein Names
CXXC-type zinc finger protein 2; F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box/LRR-repeat protein 10; JmjC domain-containing histone demethylation protein 1B; Jumonji domain-containing EMSY-interactor methyltransferase motif protein; Protein JEMMA; Protein-containing CXXC domain 2; [Histone-H3]-lysine-36 demethylase 1B
Protein Family
Lysine-specific demethylase
UniProt Gene Name
KDM2B
UniProt Synonym Gene Names
CXXC2; FBL10; FBXL10; JHDM1B; PCCX2; Protein JEMMA
UniProt Entry Name
KDM2B_HUMAN
NCBI Protein Information
lysine-specific demethylase 2B; CXXC-type zinc finger protein 2; F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box/LRR-repeat protein 10; JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein; [Histone-H3]-lysine-36 d

UniProt Comments for KDM2B

FBXL10: Histone demethylase that demethylates 'Lys-4' and 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Belongs to the JHDM1 histone demethylase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.27; Oxidoreductase; Nucleolus; Demethylase; DNA-binding

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: nucleoplasm; nucleolus; PcG protein complex; nucleus

Molecular Function: rRNA binding; protein binding; histone demethylase activity; DNA binding; zinc ion binding; histone demethylase activity (H3-K36 specific)

Biological Process: midbrain-hindbrain boundary morphogenesis; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; fourth ventricle development; negative regulation of transcription from RNA polymerase II promoter; third ventricle development; initiation of neural tube closure; histone demethylation; midbrain development; forebrain development; spermatogenesis; embryonic camera-type eye morphogenesis; negative regulation of neuron apoptosis; lateral ventricle development; hindbrain development
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KDM2B antibody

 Reference Product  PubMed Publications
 EZH2 antibody  >7 publications with KDM2B and EZH2
 PCGF1 antibody  >4 publications with KDM2B and PCGF1
 JUN antibody  >4 publications with KDM2B and JUN
 BCOR antibody  >3 publications with KDM2B and BCOR
 RNF2 antibody  >3 publications with KDM2B and RNF2
 SKP1 antibody  >3 publications with KDM2B and SKP1
 CUL1 antibody  >1 publications with KDM2B and CUL1

Pathways associated with anti-KDM2B antibody

 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 HDMs Demethylate Histones Pathway antibodies  HDMs Demethylate Histones Pathway Diagram

Diseases associated with anti-KDM2B antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >2 publications with KDM2B and Adenocarcinoma
 Nervous System Diseases Antibodies  >2 publications with KDM2B and Nervous System Diseases
 Fibrosis Antibodies  >2 publications with KDM2B and Fibrosis
 Congenital Abnormalities Antibodies  >2 publications with KDM2B and Congenital Abnormalities
 Neural Tube Defects Antibodies  >1 publications with KDM2B and Neural Tube Defects
 Neurobehavioral Manifestations Antibodies  >1 publications with KDM2B and Neurobehavioral Manifestations
 Carcinoma, Hepatocellular Antibodies  >1 publications with KDM2B and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >1 publications with KDM2B and Kidney Diseases
 Disease Models, Animal Antibodies  >1 publications with KDM2B and Disease Models, Animal

Organs/Tissues associated with anti-KDM2B antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >2 publications with KDM2B and Kidney
 Blood Antibodies  >2 publications with KDM2B and Blood
 Testis Antibodies  >2 publications with KDM2B and Testis
 Bone Antibodies  >2 publications with KDM2B and Bone
 Brain Antibodies  >2 publications with KDM2B and Brain
 Ascites Antibodies  >1 publications with KDM2B and Ascites
 Bladder Antibodies  >1 publications with KDM2B and Bladder
 Thymus Antibodies  >1 publications with KDM2B and Thymus
 Eye Antibodies  >1 publications with KDM2B and Eye
 Intestine Antibodies  >1 publications with KDM2B and Intestine
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