KDM6B Antibody – Rabbit Polyclonal

JMJD3: Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Interacts with TLE1. Component of the MLL4 complex, at least composed of MLL4, ASH2L, RBBP5, WDR5, and KDM6B. By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells. Belongs to the UTX family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 11|11 B3

Cellular Component: nucleus

Molecular Function: beta-catenin binding; chromatin binding; sequence-specific DNA binding

Biological Process: cardiac muscle cell differentiation; cell fate commitment; endothelial cell differentiation; hippocampus development; histone demethylation; mesodermal cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression