Rabbit Anti-KIRREL Polyclonal Antibody – Cat# MBS6313451

KIRREL Antibody – Rabbit Polyclonal

Name: KIRREL Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6313451
Price: 1025 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6313451

$1025 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

KIRREL, Polyclonal Antibody

Full Product Name

KIRREL, CT (KIRREL, KIRREL1, NEPH1, Kin of IRRE-like protein 1, Kin of irregular chiasm-like protein 1, Nephrin-like protein 1) (MaxLight 405)

Product Gene Name

anti-KIRREL antibody

Product Synonym Names

KIRREL; KIRREL1; NEPH1; Kin of IRRE-like protein 1; Kin of irregular chiasm-like protein 1; Nephrin-like protein 1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

72,360 Da

OMIM

607428

3D Structure

ModBase 3D Structure for Q96J84

Immunogen

KIRREL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 505-534 amino acids from the C-terminal region of human KIRREL.

Conjugate

MaxLight405

Note

Preservative Free

Product Categories/Family for anti-KIRREL antibody

Antibodies; Nephrin

Applications Tested/Suitable for anti-KIRREL antibody

Western Blot (WB), FLISA

Application Notes for anti-KIRREL antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-KIRREL antibody

Machuca, E., et al. J. Am. Soc. Nephrol. 21(7):1209-1217(2010). Wagner, M.C., et al. J. Biol. Chem. 283(51):35579-35589(2008). Hartleben, B., et al. J. Biol. Chem. 283(34):23033-23038(2008). Harita, Y., et al. J. Biol. Chem. 283(14):9177-9186(2008). Ihalmo, P., et al. Diabetologia 51(1):86-90(2008).

Other Notes

Small volumes of anti-KIRREL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KIRREL purchase

MBS6313451 is an antibody targeting KIRREL. Also known as KIRREL, CT (KIRREL, KIRREL1, NEPH1, Kin of IRRE-like protein 1, Kin of irregular chiasm-like protein 1, Nephrin-like protein 1) (MaxLight 405). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KIRREL. It may not necessarily be applicable to this product.

NCBI GI #

166295173

NCBI GeneID

55243

NCBI Accession #

NP_060710.3

UniProt Primary Accession #

Q96J84

UniProt Secondary Accession #

Q5W0F8; Q5XKC6; Q7Z696; Q7Z7N8; Q8TB15; Q9H9N1; Q9NVA5

UniProt Related Accession #

Q96J84

GenBank Nucleotide #

NM_018240.6

NCBI Official Full Name

kin of IRRE-like protein 1 isoform 1

NCBI Official Synonym Full Names

kin of IRRE like (Drosophila)

NCBI Official Symbol

KIRREL

NCBI Official Synonym Symbols

NEPH1

UniProt Protein Name

Kin of IRRE-like protein 1

UniProt Synonym Protein Names

Kin of irregular chiasm-like protein 1; Nephrin-like protein 1

Protein Family

Kin of IRRE-like protein

UniProt Gene Name

KIRREL

UniProt Synonym Gene Names

KIRREL1; NEPH1

UniProt Entry Name

KIRR1_HUMAN

NCBI Protein Information

kin of IRRE-like protein 1

NCBI Summary for KIRREL

NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM, Mar 2008]

UniProt Comments for KIRREL

Function: Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1

By similarity.

Subunit structure: Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL glycosylation. Homodimer (via the Ig-like domains). Interacts when tyrosine-phosphorylated with GRB2

By similarity.

Subcellular location: Cell membrane; Single-pass type I membrane protein

Potential. Note: Predominantly located at podocyte slit diaphragm.

Tissue specificity: Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli. Ref.1

Post-translational modification: Phosphorylation probably regulates the interaction with NSH2. Phosphorylated at Tyr-605 and Tyr-606 by FYN, leading to GRB2 binding

By similarity.N-glycosylated

By similarity.

Sequence similarities: Belongs to the immunoglobulin superfamily.Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

Sequence caution: The sequence AAP59845.1 differs from that shown. Reason: Frameshift at position 19. The sequence BAA91850.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB14192.1 differs from that shown. Reason: Erroneous initiation.

Research Articles on KIRREL

1. maintaining high levels of Neph1 at the membrane using a podocyte cell line overexpressing chimeric Neph1 increased the ability of podocytes to resist PAN-induced injury and PAN-induced albumin leakage

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-KIRREL antibody

Products by Pathway	Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram
Nephrin Interactions Pathway antibodies	Nephrin Interactions Pathway Diagram
Nephrin/Neph1 Signaling In The Kidney Podocyte Pathway antibodies	Nephrin/Neph1 Signaling In The Kidney Podocyte Pathway Diagram

Diseases associated with anti-KIRREL antibody

Disease Name	Pubmed Publications
Nerve Degeneration Antibodies	>1 publications with KIRREL and Nerve Degeneration
Edema Antibodies	>1 publications with KIRREL and Edema
Fibrosis Antibodies	>1 publications with KIRREL and Fibrosis
Inflammation Antibodies	>1 publications with KIRREL and Inflammation
Necrosis Antibodies	>1 publications with KIRREL and Necrosis

Organs/Tissues associated with anti-KIRREL antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>23 publications with KIRREL and Kidney
Brain Antibodies	>4 publications with KIRREL and Brain
Eye Antibodies	>2 publications with KIRREL and Eye
Embryonic Tissue Antibodies	>2 publications with KIRREL and Embryonic Tissue
Pancreas Antibodies	>1 publications with KIRREL and Pancreas