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KLK15 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6314303

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
KLK15, Polyclonal Antibody
Full Product Name
KLK15, ID (KLK15, Kallikrein-15, ACO protease) (PE)
Product Gene Name
anti-KLK15 antibody
Product Synonym Names
KLK15; Kallikrein-15; ACO protease
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
28,016 Da
OMIM
610601
3D Structure
ModBase 3D Structure for Q9H2R5
Immunogen
KLK15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-106 amino acids from the Central region of human KLK15.
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-KLK15 antibody

Antibodies; Kallikrein
Applications Tested/Suitable for anti-KLK15 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-KLK15 antibody
IHC: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-KLK15 antibody

KLK15 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the KLK15 antibody detected the KLK15 protein (arrow).
Rabbit Anti-KLK15 Polyclonal Antibody – Cat# MBS6314303

Immunohistochemistry (IHC) of anti-KLK15 antibody

KLK15 Antibody (Center) (AP14825c)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KLK15 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-KLK15 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6314303

Product References and Citations for anti-KLK15 antibody

Rabien, A., et al. Int. J. Cancer 127(10):2386-2394(2010). Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Han, S., et al. Hum. Immunol. 71(7):727-730(2010). Gallagher, D.J., et al. Clin. Cancer Res. 16(10):2819-2832(2010). Klein, R.J., et al. Cancer Prev Res (Phila) 3(5):611-619(2010).

Other Notes

Small volumes of anti-KLK15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KLK15 purchase

MBS6314303 is an antibody targeting KLK15. Also known as KLK15, ID (KLK15, Kallikrein-15, ACO protease) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KLK15. It may not necessarily be applicable to this product.

NCBI GI #
20302143
NCBI GeneID
55554
NCBI Accession #
NP_059979.2
NCBI Related Accession #
NP_612631.1
UniProt Primary Accession #
Q9H2R5
UniProt Secondary Accession #
Q15358; Q6ISI0; Q9H2R3; Q9H2R4; Q9H2R6; Q9HBG9; A0AUY8
UniProt Related Accession #
Q9H2R5
GenBank Nucleotide #
NM_017509.3
NCBI Official Full Name
kallikrein-15 isoform 4 preproprotein
NCBI Official Synonym Full Names
kallikrein-related peptidase 15
NCBI Official Symbol
KLK15
NCBI Official Synonym Symbols
ACO; HSRNASPH
UniProt Protein Name
Kallikrein-15
UniProt Synonym Protein Names
ACO protease
Protein Family
Kallikrein
UniProt Gene Name
KLK15
UniProt Entry Name
KLK15_HUMAN
NCBI Protein Information
kallikrein-15; ACO protease; kallikrein-like serine protease; prostinogen

NCBI Summary for KLK15

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
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UniProt Comments for KLK15

KLK15: Protease whose physiological substrate is not yet known. Belongs to the peptidase S1 family. Kallikrein subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Protease; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 19q13.41

Cellular Component: extracellular region

Molecular Function: serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: proteolysis
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Research Articles on KLK15

1. Advanced pathologic stage was associated with significantly higher expression of KLK15 and PCA3 mRNAs.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-KLK15 antibody

 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >12 publications with KLK15 and Prostatic Neoplasms
 Ovarian Neoplasms Antibodies  >7 publications with KLK15 and Ovarian Neoplasms
 Carcinoma Antibodies  >7 publications with KLK15 and Carcinoma
 Breast Neoplasms Antibodies  >5 publications with KLK15 and Breast Neoplasms
 Lung Neoplasms Antibodies  >3 publications with KLK15 and Lung Neoplasms
 Dermatitis Antibodies  >2 publications with KLK15 and Dermatitis
 Respiratory Tract Diseases Antibodies  >2 publications with KLK15 and Respiratory Tract Diseases
 Neoplasm Metastasis Antibodies  >1 publications with KLK15 and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >1 publications with KLK15 and Neoplasms, Experimental

Organs/Tissues associated with anti-KLK15 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >22 publications with KLK15 and Prostate
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