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KRT19 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6484250

MBS6484250 is an antibody targeting KRT19. Also known as KRT19, CT (Keratin, Type I Cytoskeletal 19, Cytokeratin-19, CK-19, Keratin-19, K19) (AP). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
KRT19, Polyclonal Antibody
Full Product Name
KRT19, CT (Keratin, Type I Cytoskeletal 19, Cytokeratin-19, CK-19, Keratin-19, K19) (AP)
Product Gene Name
anti-KRT19 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human KRT19.
Preparation and Storage
May be stored at 4 degree C for short-term only. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
44,106 Da
OMIM
148020
3D Structure
ModBase 3D Structure for P08727
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 336-365 in the C-terminal region of human KRT19, UniProt Accession #P08727.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-KRT19 antibody

Antibodies; Keratin; Cytokeratin
Applications Tested/Suitable for anti-KRT19 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-KRT19 antibody
WB: 1:50-1:100
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-KRT19 antibody

Western Blot analysis in CEM cell line lysates (35ug/lane) usingMBS6002256. KRT19 (arrow) was detected using the purified Pab.
Rabbit Anti-KRT19 Polyclonal Antibody – Cat# MBS6484250

Immunohistochemistry (IHC) of anti-KRT19 antibody

IHC analysis in formalin fixed and paraffin embedded human Lung carcinoma using MBS6002256 followed by peroxidase conjugation of the secondary antibody and DAB staining.
Rabbit Anti-KRT19 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6484250

Product References and Citations for anti-KRT19 antibody

1. Bonzanini, M., Acta Cytol. 52(5), 541-548 (2008). 2. Yang, X.R., Clin. Cancer Res. 14(12), 3850-3859 (2008). 3. Maurer, J., PLoS ONE 3(10), E3451 (2008).

Other Notes

Small volumes of anti-KRT19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KRT19. It may not necessarily be applicable to this product.

NCBI GI #
24234699
NCBI GeneID
3880
NCBI Accession #
NP_002267
UniProt Primary Accession #
P08727
UniProt Secondary Accession #
Q5XG83; Q6NW33; Q7L5M9; Q96A53; Q96FV1; Q9BYF9; Q9P1Y4; B2R874
UniProt Related Accession #
P08727
GenBank Nucleotide #
NM_002276.4
NCBI Official Full Name
keratin, type I cytoskeletal 19
NCBI Official Synonym Full Names
keratin 19
NCBI Official Symbol
KRT19
NCBI Official Synonym Symbols
K19; CK19; K1CS
UniProt Protein Name
Keratin, type I cytoskeletal 19
UniProt Synonym Protein Names
Cytokeratin-19; CK-19; Keratin-19
Protein Family
Keratin
UniProt Gene Name
KRT19
UniProt Synonym Gene Names
CK-19; K19
UniProt Entry Name
K1C19_HUMAN
NCBI Protein Information
keratin, type I cytoskeletal 19

NCBI Summary for KRT19

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
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UniProt Comments for KRT19

K19: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 19 differs from all other IF proteins in lacking the C-terminal tail domain. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: dystrophin-associated glycoprotein complex; costamere; intermediate filament; Z disc; sarcolemma

Molecular Function: protein binding; structural constituent of cytoskeleton; structural constituent of muscle; protein complex binding

Biological Process: viral reproduction; response to estrogen stimulus; sarcomere organization
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Research Articles on KRT19

1. Our results are of special importance against the background that CK19 positive carcinomas revealed a significantly poorer prognosis and therefore emphasize its prognostic and possible diagnostic role in tongue cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KRT19 antibody

 Reference Product  PubMed Publications
 KRT15 antibody  >3 publications with KRT19 and KRT15
 KRT6B antibody  >1 publications with KRT19 and KRT6B
 FANCG antibody  >1 publications with KRT19 and FANCG

Pathways associated with anti-KRT19 antibody

 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Keratinization Pathway antibodies  Keratinization Pathway Diagram
 Signaling Mediated By P38-alpha And P38-beta Pathway antibodies  Signaling Mediated By P38-alpha And P38-beta Pathway Diagram

Diseases associated with anti-KRT19 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >42 publications with KRT19 and Neoplasms
 Carcinoma Antibodies  >25 publications with KRT19 and Carcinoma
 Adenocarcinoma Antibodies  >13 publications with KRT19 and Adenocarcinoma
 Breast Neoplasms Antibodies  >9 publications with KRT19 and Breast Neoplasms
 Liver Diseases Antibodies  >8 publications with KRT19 and Liver Diseases
 Neoplasm Metastasis Antibodies  >7 publications with KRT19 and Neoplasm Metastasis
 Liver Neoplasms Antibodies  >5 publications with KRT19 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >5 publications with KRT19 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >4 publications with KRT19 and Kidney Diseases
 Fibrosis Antibodies  >4 publications with KRT19 and Fibrosis

Organs/Tissues associated with anti-KRT19 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >12 publications with KRT19 and Liver
 Blood Antibodies  >12 publications with KRT19 and Blood
 Lung Antibodies  >6 publications with KRT19 and Lung
 Bone Antibodies  >5 publications with KRT19 and Bone
 Kidney Antibodies  >4 publications with KRT19 and Kidney
 Thyroid Antibodies  >4 publications with KRT19 and Thyroid
 Eye Antibodies  >3 publications with KRT19 and Eye
 Stomach Antibodies  >3 publications with KRT19 and Stomach
 Pancreas Antibodies  >3 publications with KRT19 and Pancreas
 Lymph Antibodies  >2 publications with KRT19 and Lymph
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