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MAGEA6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1494851

Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or… More details

$230 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MAGEA6, Polyclonal Antibody
Full Product Name
Rabbit anti-human MAGEA6 polyclonal Antibody
Product Gene Name
Product Synonym Names
Cancer/testis antigen 1.6; CT1.6; MAGE-6 antigen; MAGE3B antigen; MAGEA6; MAGE6
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Molecular Weight
34,891 Da
OMIM
300176
3D Structure
ModBase 3D Structure for P43360
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Melanoma-associated antigen 6 protein (19-148aa)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MAGEA6 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-MAGEA6 antibody
Recommended dilution: WB:1:500-2000
IHC:1:20-1:200

Western Blot (WB) of anti-MAGEA6 antibody

All lanes: MAGEA6 antibody at 7ug/ml
Lane 1:rat brain tissue
Lane 2:rat gonad tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 35kDa
Observed band size: 35kDa
Rabbit Anti-MAGEA6 Polyclonal Antibody – Cat# MBS1494851

Immunohistochemistry (IHC) of anti-MAGEA6 antibody

Immunohistochemistry of paraffin-embedded human testis using MBS1494851 at dilution 1:100
Rabbit Anti-MAGEA6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1494851

Immunohistochemistry (IHC) of anti-MAGEA6 antibody

Immunohistochemistry of paraffin-embedded human lung cancer using MBS1494851 at dilution 1:100
Rabbit Anti-MAGEA6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1494851

Other Notes

Small volumes of anti-MAGEA6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAGEA6 purchase

MBS1494851 is an antibody targeting MAGEA6. Also known as Rabbit anti-human MAGEA6 polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MAGEA6. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
melanoma-associated antigen 6
NCBI Official Synonym Full Names
MAGE family member A6
NCBI Official Symbol
MAGEA6
NCBI Official Synonym Symbols
CT1.6; MAGE6; MAGE3B; MAGE-3b
UniProt Protein Name
Melanoma-associated antigen 6
UniProt Synonym Protein Names
Cancer/testis antigen 1.6; CT1.6; MAGE-6 antigen; MAGE3B antigen
UniProt Gene Name
MAGEA6
UniProt Synonym Gene Names
MAGE6; CT1.6
UniProt Entry Name
MAGA6_HUMAN
NCBI Protein Information
melanoma-associated antigen 6

NCBI Summary for MAGEA6

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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UniProt Comments for MAGEA6

MAGE-A6: Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.

Protein type: Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: Xq28

Molecular Function: protein binding
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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