MAP2K6 Antibody – Rabbit Polyclonal

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]

MKK6: a dual-specificity protein kinase of the STE7 family. Activates p38 MAP kinase by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by cytokines and environmental stress in vivo. Three alternatively spliced isoforms have been reported.

Protein type: Kinase, protein; EC 2.7.12.2; Protein kinase, dual-specificity (non-receptor); Protein kinase, STE; STE group; STE7 family

Chromosomal Location of Human Ortholog: 17q24.3

Cellular Component: cytoplasm; cytoskeleton; cytosol; nucleoplasm

Molecular Function: ATP binding; MAP kinase kinase activity; protein binding; protein kinase binding; protein serine/threonine kinase activity; protein-tyrosine kinase activity

Biological Process: activation of MAPK activity; apoptosis; cardiac muscle contraction; cell cycle arrest; DNA damage induced protein phosphorylation; innate immune response; muscle cell differentiation; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; ovulation cycle process; peptidyl-tyrosine phosphorylation; positive regulation of apoptosis; positive regulation of muscle cell differentiation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of prostaglandin secretion; regulation of apoptosis; regulation of mitotic cell cycle; regulation of transcription, DNA-dependent; response to drug; signal transduction; stress-activated MAPK cascade; stress-activated protein kinase signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; transcription, DNA-dependent