MAT2B Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

MAT2B: Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S- adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S- adenosylmethionine inhibition. Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; Other Amino Acids Metabolism - selenoamino acid; Amino Acid Metabolism - cysteine and methionine

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: methionine adenosyltransferase complex; mitochondrion; intracellular; cytosol; nucleus

Molecular Function: enzyme binding; methionine adenosyltransferase regulator activity

Biological Process: methylation; regulation of catalytic activity; xenobiotic metabolic process; S-adenosylmethionine biosynthetic process; one-carbon compound metabolic process