Rabbit Anti-MC4R Polyclonal Antibody – Cat# MBS9447418

MC4R Antibody – Rabbit Polyclonal

Name: MC4R Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS9447418
Price: 435 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9447418

The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this… More details

$435 / 0.1 mL (Biotin) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MC4R, Polyclonal Antibody

Full Product Name

MC4R Conjugated Antibody

Product Gene Name

anti-MC4R antibody

Product Synonym Names

MC4-R; MC4R; MGC126851; MGC138197

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

Specificity

The antibody detects endogenous levels of total MC4R protein.

Preparation and Storage

Store at 4 degree C for 6 months.

Molecular Weight

36,943 Da

OMIM

155541

3D Structure

ModBase 3D Structure for P32245

Immunogen

Synthetic peptide corresponding to residues near the N terminal of human Melanocortin 4 receptor

Conjugation

Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750

Excitation Emission

AF350: 346nm/442nm

Applications Tested/Suitable for anti-MC4R antibody

Most Applications

Application Notes for anti-MC4R antibody

Suggested Dilution:
AF350 conjugated: most applications: 1:50-1:250
AF405 conjugated: most applications: 1:50-1:250
AF488 conjugated: most applications: 1:50-1:250
AF555 conjugated: most applications: 1:50-1:250
AF594 conjugated: most applications: 1:50-1:250
AF647 conjugated: most applications: 1:50-1:250
AF680 conjugated: most applications: 1:50-1:250
AF750 conjugated: most applications: 1:50-1:250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000

Other Notes

Small volumes of anti-MC4R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MC4R purchase

MBS9447418 is an antibody targeting MC4R. Also known as MC4R Conjugated Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MC4R. It may not necessarily be applicable to this product.

NCBI GI #

119508433

NCBI GeneID

4160

NCBI Accession #

NP_005903

UniProt Primary Accession #

P32245

UniProt Secondary Accession #

Q16317; Q3MIJ6; B2RAC3

UniProt Related Accession #

P32245

GenBank Nucleotide #

NM_005912.2

NCBI Official Full Name

melanocortin receptor 4

NCBI Official Synonym Full Names

melanocortin 4 receptor

NCBI Official Symbol

MC4R

UniProt Protein Name

Melanocortin receptor 4

Protein Family

Melanocortin receptor

UniProt Gene Name

MC4R

UniProt Synonym Gene Names

MC4-R

UniProt Entry Name

MC4R_HUMAN

NCBI Protein Information

melanocortin receptor 4; MC4-R

NCBI Summary for MC4R

UniProt Comments for MC4R

MC4R: receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. A G-protein coupled receptor that stimulates adenylate cyclase. Defects are a cause of autosomal dominant obesity

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 18q22

Cellular Component: integral to membrane; plasma membrane; nucleus

Molecular Function: neuropeptide binding; protein binding; melanocortin receptor activity; peptide hormone binding; ubiquitin protein ligase binding; melanocyte stimulating hormone receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; diet induced thermogenesis; insulin secretion; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; positive regulation of bone resorption; feeding behavior; response to insulin stimulus

Disease: Obesity

Research Articles on MC4R

1. We identified differences in the striatal response to food cues between two groups of obese individuals, those with and those without MC4R mutations.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MC4R antibody

Reference Product	PubMed Publications
POMC antibody	>302 publications with MC4R and POMC
AGRP antibody	>111 publications with MC4R and AGRP
MC1R antibody	>70 publications with MC4R and MC1R
NPY antibody	>48 publications with MC4R and NPY
ASIP antibody	>9 publications with MC4R and ASIP

Pathways associated with anti-MC4R antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies	Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-MC4R antibody

Disease Name	Pubmed Publications
Obesity Antibodies	>503 publications with MC4R and Obesity
Body Weight Antibodies	>476 publications with MC4R and Body Weight
Weight Gain Antibodies	>71 publications with MC4R and Weight Gain
Weight Loss Antibodies	>67 publications with MC4R and Weight Loss
Hyperphagia Antibodies	>63 publications with MC4R and Hyperphagia
Insulin Resistance Antibodies	>46 publications with MC4R and Insulin Resistance
Hyperinsulinism Antibodies	>38 publications with MC4R and Hyperinsulinism
Hypertension Antibodies	>31 publications with MC4R and Hypertension
Cardiovascular Diseases Antibodies	>29 publications with MC4R and Cardiovascular Diseases
Inflammation Antibodies	>22 publications with MC4R and Inflammation

Organs/Tissues associated with anti-MC4R antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>234 publications with MC4R and Brain