Rabbit Anti-MCPH1 Polyclonal Antibody – Cat# MBS6013133

MCPH1 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the MCPH1 antibody detected the MCPH1 protein (arrow).

MCPH1 Antibody – Rabbit Polyclonal

Name: MCPH1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6013133
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6013133

This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MCPH1, Polyclonal Antibody

Full Product Name

MCPH1, NT (MCPH1, Microcephalin)

Product Gene Name

anti-MCPH1 antibody

Product Synonym Names

Anti -MCPH1, NT (MCPH1, Microcephalin)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

92,877 Da

Chromosome Location

Chromosome: 8; NC_000008.10 (6264113..6501140). Location: 8p23.1

OMIM

251200

3D Structure

ModBase 3D Structure for Q8NEM0

Immunogen

MCPH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-133 amino acids from the N-terminal region of human MCPH1.

Product Categories/Family for anti-MCPH1 antibody

Antibodies; Abs to Disease Markers

Applications Tested/Suitable for anti-MCPH1 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-MCPH1 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-MCPH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCPH1 purchase

MBS6013133 is an antibody targeting MCPH1. Also known as MCPH1, NT (MCPH1, Microcephalin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MCPH1. It may not necessarily be applicable to this product.

NCBI GI #

289191318

NCBI GeneID

79648

NCBI Accession #

NP_001166046.1

UniProt Primary Accession #

Q8NEM0

UniProt Secondary Accession #

Q66GU1; Q9H9C7; B4DWW2; E9PGU5; E9PH63

UniProt Related Accession #

Q8NEM0

GenBank Nucleotide #

NM_001172575.1

NCBI Official Full Name

microcephalin isoform 3

NCBI Official Synonym Full Names

microcephalin 1

NCBI Official Symbol

MCPH1

NCBI Official Synonym Symbols

MCT; BRIT1

UniProt Protein Name

Microcephalin

Protein Family

Microcephalin

UniProt Gene Name

MCPH1

UniProt Entry Name

MCPH1_HUMAN

NCBI Protein Information

microcephalin; BRCT-repeat inhibitor of TERT expression 1

UniProt Comments for MCPH1

MCPH1: a DNA damage responsive protein and transcriptional repressor of human telomere reverse transcriptase. An early responder to DNA damage. Required for double strand break repair via homologous recombination and nonhomologous end joining. Promotes chromatin relaxation by recruiting and maintaining the chromatin remodeling SWI-SNF complex at sites of DNA double strand breakage. Participates in the ATR/Chk1-mediated DNA checkpoint in humans and transcriptionally regulates BRCA1 and Chk1. Plays a role in neurogenesis and regulation of the size of the cerebral cortex. Mutations of MCPH1 can cause microcephaly in humans and appears to play an evolutionarily conserved role in brain development. Alterations have been identified in breast, ovarian and prostate cancer. Appears to coordinate S-M transitions in fly embryos.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: nucleoplasm; cytoplasm; microtubule organizing center

Molecular Function: identical protein binding; protein binding

Biological Process: mitotic cell cycle; cerebral cortex development

Disease: Microcephaly 1, Primary, Autosomal Recessive

Research Articles on MCPH1

1. The MCPH1 polymorphisms and protein expression were associated with tumorigenesis in breast cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MCPH1 antibody

Reference Product	PubMed Publications
ASPM antibody	>39 publications with MCPH1 and ASPM
CDK5RAP2 antibody	>13 publications with MCPH1 and CDK5RAP2
ATM antibody	>8 publications with MCPH1 and ATM
MDC1 antibody	>5 publications with MCPH1 and MDC1
STIL antibody	>5 publications with MCPH1 and STIL
RAD51 antibody	>5 publications with MCPH1 and RAD51
BRCA2 antibody	>4 publications with MCPH1 and BRCA2
H2AFX antibody	>3 publications with MCPH1 and H2AFX
CHD4 antibody	>1 publications with MCPH1 and CHD4

Diseases associated with anti-MCPH1 antibody

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>55 publications with MCPH1 and Congenital Abnormalities
MICROCEPHALY 1, PRIMARY, AUTOSOMAL RECESSIVE Antibodies	>20 publications with MCPH1 and MICROCEPHALY 1, PRIMARY, AUTOSOMAL RECESSIVE
Neoplasms Antibodies	>19 publications with MCPH1 and Neoplasms
Autistic Disorder Antibodies	>5 publications with MCPH1 and Autistic Disorder
Growth Disorders Antibodies	>3 publications with MCPH1 and Growth Disorders
Death Antibodies	>2 publications with MCPH1 and Death
Disease Models, Animal Antibodies	>2 publications with MCPH1 and Disease Models, Animal
Memory Disorders Antibodies	>1 publications with MCPH1 and Memory Disorders
Prenatal Exposure Delayed Effects Antibodies	>1 publications with MCPH1 and Prenatal Exposure Delayed Effects
Learning Disorders Antibodies	>1 publications with MCPH1 and Learning Disorders

Organs/Tissues associated with anti-MCPH1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>64 publications with MCPH1 and Brain
Heart Antibodies	>1 publications with MCPH1 and Heart
Eye Antibodies	>1 publications with MCPH1 and Eye