Rabbit Anti-MCPH1 Polyclonal Antibody – Cat# MBS6319766

MCPH1 Antibody – Rabbit Polyclonal

Name: MCPH1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6319766
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6319766

This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal… More details

$1060 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MCPH1, Polyclonal Antibody

Full Product Name

MCPH1, NT (MCPH1, Microcephalin) (MaxLight 490)

Product Gene Name

anti-MCPH1 antibody

Product Synonym Names

MCPH1; Microcephalin

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

67,915 Da

OMIM

251200

3D Structure

ModBase 3D Structure for Q8NEM0

Immunogen

MCPH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-133 amino acids from the N-terminal region of human MCPH1.

Conjugate

MaxLight490

Note

Preservative Free

Product Categories/Family for anti-MCPH1 antibody

Antibodies; Disease Markers

Applications Tested/Suitable for anti-MCPH1 antibody

Western Blot (WB), FLISA

Application Notes for anti-MCPH1 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-MCPH1 antibody

Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010). Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Olson, J.E., et al. Breast Cancer Res. Treat. (2010). In press: Wang, Y.Q., et al. Hum. Mol. Genet. 13(11):1131-1137(2004).

Other Notes

Small volumes of anti-MCPH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCPH1 purchase

MBS6319766 is an antibody targeting MCPH1. Also known as MCPH1, NT (MCPH1, Microcephalin) (MaxLight 490). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MCPH1. It may not necessarily be applicable to this product.

NCBI GI #

122891872

NCBI GeneID

79648

NCBI Accession #

NP_078872.2

NCBI Related Accession #

NP_001166045.1

UniProt Primary Accession #

Q8NEM0

UniProt Secondary Accession #

Q66GU1; Q9H9C7; B4DWW2; E9PGU5; E9PH63

UniProt Related Accession #

Q8NEM0

GenBank Nucleotide #

NM_024596.3

NCBI Official Full Name

microcephalin isoform 1

NCBI Official Synonym Full Names

microcephalin 1

NCBI Official Symbol

MCPH1

NCBI Official Synonym Symbols

MCT; BRIT1

UniProt Protein Name

Microcephalin

Protein Family

Microcephalin

UniProt Gene Name

MCPH1

UniProt Entry Name

MCPH1_HUMAN

NCBI Protein Information

microcephalin

UniProt Comments for MCPH1

MCPH1: a DNA damage responsive protein and transcriptional repressor of human telomere reverse transcriptase. An early responder to DNA damage. Required for double strand break repair via homologous recombination and nonhomologous end joining. Promotes chromatin relaxation by recruiting and maintaining the chromatin remodeling SWI-SNF complex at sites of DNA double strand breakage. Participates in the ATR/Chk1-mediated DNA checkpoint in humans and transcriptionally regulates BRCA1 and Chk1. Plays a role in neurogenesis and regulation of the size of the cerebral cortex. Mutations of MCPH1 can cause microcephaly in humans and appears to play an evolutionarily conserved role in brain development. Alterations have been identified in breast, ovarian and prostate cancer. Appears to coordinate S-M transitions in fly embryos.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: nucleoplasm; cytoplasm; microtubule organizing center

Molecular Function: identical protein binding; protein binding

Biological Process: mitotic cell cycle; cerebral cortex development

Disease: Microcephaly 1, Primary, Autosomal Recessive

Research Articles on MCPH1

1. Data indicate splice-acceptor site homozygous mutation in intron 4 of microcephalin (MCPH1) gene in 2 children.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MCPH1 antibody

Reference Product	PubMed Publications
SET antibody	>10 publications with MCPH1 and SET
BRCA2 antibody	>4 publications with MCPH1 and BRCA2
CDC27 antibody	>2 publications with MCPH1 and CDC27
CHD4 antibody	>1 publications with MCPH1 and CHD4
NCAPG2 antibody	>1 publications with MCPH1 and NCAPG2

Pathways associated with anti-MCPH1 antibody

Products by Pathway	Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
Condensation Of Prophase Chromosomes Pathway antibodies	Condensation Of Prophase Chromosomes Pathway Diagram
M Phase Pathway antibodies	M Phase Pathway Diagram
Mitotic Prophase Pathway antibodies	Mitotic Prophase Pathway Diagram

Diseases associated with anti-MCPH1 antibody

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>68 publications with MCPH1 and Congenital Abnormalities
Ovarian Neoplasms Antibodies	>5 publications with MCPH1 and Ovarian Neoplasms
Cell Transformation, Neoplastic Antibodies	>3 publications with MCPH1 and Cell Transformation, Neoplastic
Learning Disorders Antibodies	>2 publications with MCPH1 and Learning Disorders
Memory Disorders Antibodies	>2 publications with MCPH1 and Memory Disorders
Liver Diseases Antibodies	>2 publications with MCPH1 and Liver Diseases
Liver Neoplasms Antibodies	>2 publications with MCPH1 and Liver Neoplasms
Neoplasm Metastasis Antibodies	>2 publications with MCPH1 and Neoplasm Metastasis
Heart Defects, Congenital Antibodies	>1 publications with MCPH1 and Heart Defects, Congenital
Cognition Disorders Antibodies	>1 publications with MCPH1 and Cognition Disorders

Organs/Tissues associated with anti-MCPH1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>79 publications with MCPH1 and Brain
Embryonic Tissue Antibodies	>5 publications with MCPH1 and Embryonic Tissue
Lung Antibodies	>4 publications with MCPH1 and Lung
Lymph Node Antibodies	>3 publications with MCPH1 and Lymph Node
Prostate Antibodies	>2 publications with MCPH1 and Prostate
Uncharacterized Tissue Antibodies	>1 publications with MCPH1 and Uncharacterized Tissue