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MGST2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6488070

MBS6488070 is an antibody targeting MGST2. Also known as MGST2, CT (Microsomal Glutathione S-transferase 2, Microsomal GST-2, Microsomal GST-II, MGST-II, FLJ27438, GST2, MGC14097) (MaxLight 490). Reactive in Human. Host: Rabbit. More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MGST2, Polyclonal Antibody
Full Product Name
MGST2, CT (Microsomal Glutathione S-transferase 2, Microsomal GST-2, Microsomal GST-II, MGST-II, FLJ27438, GST2, MGC14097) (MaxLight 490)
Product Gene Name
anti-MGST2 antibody
Product Synonym Names
EC=2.5.1.18
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.
Purity/Purification
Purified by Ammonium Sulfate Precipitation.
Specificity
Recognizes human MGST2.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
16kDa
OMIM
601733
3D Structure
ModBase 3D Structure for Q99735
Immunogen
Synthetic peptide selected from the C-terminal region of human MGST2 (KLH).
Conjugate
MaxLight490
Note
Preservative Free

Product Categories/Family for anti-MGST2 antibody

Antibodies; Enzymes
Applications Tested/Suitable for anti-MGST2 antibody
Western Blot (WB), FLISA
Application Notes for anti-MGST2 antibody
WB: 1:50-1:100
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-MGST2 antibody

Western blot analysis of MGST2 Antibody (C-term) in HepG2 cell line lysates (35ug/lane). MGST2 (arrow) was detected using the purified Pab.
Rabbit Anti-MGST2 Polyclonal Antibody – Cat# MBS6488070

Immunohistochemistry (IHC) of anti-MGST2 antibody

Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with MGST2 Antibody (C-term),which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-MGST2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6488070

Flow Cytometry (FC/FACS) of anti-MGST2 antibody

MGST2 Antibody (C-term) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-MGST2 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6488070

Product References and Citations for anti-MGST2 antibody

1. Jakobsson, P.J., et.al., Am. J. Respir. Crit. Care Med. 161(2 PT 2), S20-S24 (2000). 2. Sjostrom, M., et.al., Eur. J. Biochem. 268(9), 2578-2586 (2001).

Other Notes

Small volumes of anti-MGST2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MGST2. It may not necessarily be applicable to this product.

NCBI GI #
4505181
NCBI GeneID
4258
NCBI Accession #
NP_002404
UniProt Primary Accession #
Q99735
UniProt Related Accession #
Q99735
GenBank Nucleotide #
NM_002413
NCBI Official Full Name
microsomal glutathione S-transferase 2 isoform 1
NCBI Official Synonym Full Names
microsomal glutathione S-transferase 2
NCBI Official Symbol
MGST2
NCBI Official Synonym Symbols
GST2; MGST-II
UniProt Protein Name
Microsomal glutathione S-transferase 2
UniProt Synonym Protein Names
Microsomal GST-II
Protein Family
Microsomal glutathione S-transferase
UniProt Gene Name
MGST2
UniProt Synonym Gene Names
GST2; Microsomal GST-2
UniProt Entry Name
MGST2_HUMAN
NCBI Protein Information
microsomal glutathione S-transferase 2

NCBI Summary for MGST2

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]
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UniProt Comments for MGST2

MGST2: Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione. Belongs to the MAPEG family.

Protein type: Membrane protein, integral; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 2.5.1.18; Endoplasmic reticulum; Membrane protein, multi-pass; Xenobiotic Metabolism - metabolism by cytochrome P450; Transferase; Other Amino Acids Metabolism - glutathione

Chromosomal Location of Human Ortholog: 4q28.3

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; integral to membrane; plasma membrane; nuclear envelope

Molecular Function: glutathione transferase activity; leukotriene-C4 synthase activity; enzyme activator activity; glutathione peroxidase activity

Biological Process: leukotriene biosynthetic process; positive regulation of catalytic activity; xenobiotic metabolic process; glutathione biosynthetic process; response to lipopolysaccharide; response to organic nitrogen
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Research Articles on MGST2

1. Trimeric microsomal protein MGST2 displays one third of the sites reactivity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MGST2 antibody

 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Glutathione Conjugation Pathway antibodies  Glutathione Conjugation Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Phase II Conjugation Pathway antibodies  Phase II Conjugation Pathway Diagram

Diseases associated with anti-MGST2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >6 publications with MGST2 and Inflammation
 Drug Toxicity Antibodies  >5 publications with MGST2 and Drug Toxicity
 Cardiovascular Diseases Antibodies  >4 publications with MGST2 and Cardiovascular Diseases
 Liver Diseases Antibodies  >4 publications with MGST2 and Liver Diseases
 Psoriasis Antibodies  >2 publications with MGST2 and Psoriasis
 Body Weight Changes Antibodies  >1 publications with MGST2 and Body Weight Changes
 Poisoning Antibodies  >1 publications with MGST2 and Poisoning
 Hepatitis Antibodies  >1 publications with MGST2 and Hepatitis
 Necrosis Antibodies  >1 publications with MGST2 and Necrosis
 Neoplasms Antibodies  >1 publications with MGST2 and Neoplasms

Organs/Tissues associated with anti-MGST2 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >10 publications with MGST2 and Liver
 Blood Antibodies  >6 publications with MGST2 and Blood
 Skin Antibodies  >3 publications with MGST2 and Skin
 Vascular Antibodies  >2 publications with MGST2 and Vascular
 Embryonic Tissue Antibodies  >2 publications with MGST2 and Embryonic Tissue
 Muscle Antibodies  >2 publications with MGST2 and Muscle
 Eye Antibodies  >2 publications with MGST2 and Eye
 Brain Antibodies  >2 publications with MGST2 and Brain
 Heart Antibodies  >1 publications with MGST2 and Heart
 Adrenal Gland Antibodies  >1 publications with MGST2 and Adrenal Gland
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