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MINPP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643571

This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts… More details

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Product Overview

Online Datasheet in PDF
Product Name
MINPP1, Polyclonal Antibody
Full Product Name
MINPP1, CT (MINPP1, MIPP, Multiple inositol polyphosphate phosphatase 1, 2,3-bisphosphoglycerate 3-phosphatase, Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase)
Product Gene Name
anti-MINPP1 antibody
Product Synonym Names
Anti -MINPP1, CT (MINPP1, MIPP, Multiple inositol polyphosphate phosphatase 1, 2,3-bisphosphoglycerate 3-phosphatase, Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
55,051 Da
Chromosome Location
Chromosome: 10; NC_000010.10 (89264223..89313218). Location: 10q23
OMIM
605391
3D Structure
ModBase 3D Structure for Q9UNW1
Immunogen
MINPP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-348 amino acids from the C-terminal region of human MINPP1.

Product Categories/Family for anti-MINPP1 antibody

Antibodies; Abs to Enzymes; Phosphatase
Applications Tested/Suitable for anti-MINPP1 antibody
ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-MINPP1 antibody
Suitable for use in Western Blot, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-MINPP1 antibody

MINPP1 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MINPP1 antibody detected the MINPP1 protein (arrow).
Rabbit Anti-MINPP1 Polyclonal Antibody – Cat# MBS643571

Flow Cytometry (FC/FACS) of anti-MINPP1 antibody

MINPP1 Antibody (C-term) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-MINPP1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS643571

Other Notes

Small volumes of anti-MINPP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MINPP1 purchase

MBS643571 is an antibody targeting MINPP1. Also known as MINPP1, CT (MINPP1, MIPP, Multiple inositol polyphosphate phosphatase 1, 2,3-bisphosphoglycerate 3-phosphatase, Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MINPP1. It may not necessarily be applicable to this product.

NCBI GI #
296010988
NCBI GeneID
9562
NCBI Accession #
NP_001171589.1
UniProt Primary Accession #
Q9UNW1
UniProt Secondary Accession #
O95172; O95286; Q59EJ2; Q9UGA3; F5H683
UniProt Related Accession #
Q9UNW1
GenBank Nucleotide #
NM_001178118.1
NCBI Official Full Name
multiple inositol polyphosphate phosphatase 1 isoform 3
NCBI Official Synonym Full Names
multiple inositol-polyphosphate phosphatase 1
NCBI Official Symbol
MINPP1
NCBI Official Synonym Symbols
MIPP; HIPER1; MINPP2
UniProt Protein Name
Multiple inositol polyphosphate phosphatase 1
UniProt Synonym Protein Names
2,3-bisphosphoglycerate 3-phosphatase (EC:3.1.3.80); 2,3-BPG phosphatase; Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; Ins(1,3,4,5)P(4) 3-phosphatase
Protein Family
Multiple inositol polyphosphate phosphatase
UniProt Gene Name
MINPP1
UniProt Synonym Gene Names
MIPP; 2,3-BPG phosphatase; Ins(1,3,4,5)P(4) 3-phosphatase
UniProt Entry Name
MINP1_HUMAN
NCBI Protein Information
multiple inositol polyphosphate phosphatase 1; 2,3-BPG phosphatase; ins(1,3,4,5)P(4) 3-phosphatase; 2,3-bisphosphoglycerate 3-phosphatase; multiple inositol polyphosphate phosphatase 2; inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; multiple inositol polyphosphate histidine phosphatase, 1

UniProt Comments for MINPP1

MINPP1: Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3- phosphoglycerate. May play a role in bone development (endochondral ossification). Defects in MINPP1 may be involved in follicular thyroid tumors development. Belongs to the histidine acid phosphatase family. MINPP1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.62; Motility/polarity/chemotaxis; Hydrolase; Carbohydrate Metabolism - inositol phosphate; Secreted, signal peptide; Secreted; EC 3.1.3.80

Chromosomal Location of Human Ortholog: 10q23

Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen

Molecular Function: acid phosphatase activity; phosphohistidine phosphatase activity

Biological Process: polyphosphate metabolic process; ossification; inositol phosphate metabolic process; dephosphorylation; bone mineralization

Disease: Thyroid Carcinoma, Follicular
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Research Articles on MINPP1

1. By RNA knockdown, we identified secreted and lysosome targeted MINPP1 (multiple inositol-polyphosphate phosphatase 1), the mammalian 3-phytase, to be essentially involved both in extracellular and in lysosomal InsP6 dephosphorylation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MINPP1 antibody

 Products by Pathway  Pathway Diagram
 D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol (1,4,5,6)-tetrakisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,4,5,6)-tetrakisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol (1,4,5,6)-tetrakisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,4,5,6)-tetrakisphosphate Biosynthesis Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Rapoport-Luebering Glycolytic Shunt Pathway antibodies  Rapoport-Luebering Glycolytic Shunt Pathway Diagram
 Rapoport-Luebering Glycolytic Shunt Pathway antibodies  Rapoport-Luebering Glycolytic Shunt Pathway Diagram

Diseases associated with anti-MINPP1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with MINPP1 and Neoplasms
 Embryo Loss Antibodies  >1 publications with MINPP1 and Embryo Loss
 Genital Diseases, Male Antibodies  >1 publications with MINPP1 and Genital Diseases, Male
 Hypertrophy Antibodies  >1 publications with MINPP1 and Hypertrophy
 Thyroid cancer, follicular Antibodies  >1 publications with MINPP1 and Thyroid cancer, follicular

Organs/Tissues associated with anti-MINPP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2 publications with MINPP1 and Bone
 Prostate Antibodies  >1 publications with MINPP1 and Prostate
 Embryonic Tissue Antibodies  >1 publications with MINPP1 and Embryonic Tissue
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