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MIP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9446586

Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated… More details

$435 / 0.1 mL (Biotin) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MIP, Polyclonal Antibody
Full Product Name
MIP Conjugated Antibody
Product Gene Name
anti-MIP antibody
Product Synonym Names
AQP0; LIM1; MP26; MIP26; CTRCT15
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
Specificity
The antibody detects endogenous levels of total MIP protein.
Preparation and Storage
Store at 4 degree C for 6 months.
Molecular Weight
28,122 Da
OMIM
gene 615274
3D Structure
ModBase 3D Structure for P30301
Immunogen
Fusion protein corresponding to a region derived from internal residues of human major intrinsic protein of lens fiber
Conjugation
Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
Excitation Emission
AF350: 346nm/442nm
Applications Tested/Suitable for anti-MIP antibody
Most Applications
Application Notes for anti-MIP antibody
Suggested Dilution:
AF350 conjugated: most applications: 1:50-1:250
AF405 conjugated: most applications: 1:50-1:250
AF488 conjugated: most applications: 1:50-1:250
AF555 conjugated: most applications: 1:50-1:250
AF594 conjugated: most applications: 1:50-1:250
AF647 conjugated: most applications: 1:50-1:250
AF680 conjugated: most applications: 1:50-1:250
AF750 conjugated: most applications: 1:50-1:250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000

Other Notes

Small volumes of anti-MIP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MIP purchase

MBS9446586 is an antibody targeting MIP. Also known as MIP Conjugated Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MIP. It may not necessarily be applicable to this product.

NCBI GI #
109658633
NCBI GeneID
4284
NCBI Accession #
BC117474
UniProt Primary Accession #
P30301
UniProt Secondary Accession #
Q17R41
UniProt Related Accession #
P30301
NCBI Official Full Name
Homo sapiens major intrinsic protein of lens fiber, mRNA
NCBI Official Synonym Full Names
major intrinsic protein of lens fiber
NCBI Official Symbol
MIP
NCBI Official Synonym Symbols
AQP0; LIM1; MP26; MIP26; CTRCT15
UniProt Protein Name
Lens fiber major intrinsic protein
UniProt Synonym Protein Names
Aquaporin-0; MIP26; MP26
Protein Family
Allatostatins
UniProt Gene Name
MIP
UniProt Synonym Gene Names
AQP0; MP26
UniProt Entry Name
MIP_HUMAN
NCBI Protein Information
lens fiber major intrinsic protein

UniProt Comments for MIP

AQP0: major intrinsic protein of lens fiber. A member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. May be responsible for regulating the osmolarity of the lens. Defects in MIP are a cause of autosomal recessive congenital cataract.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, misc.; Transporter, aquaporin family

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: intracellular canaliculus; intracellular membrane-bound organelle; integral to plasma membrane; apical plasma membrane; plasma membrane; gap junction

Molecular Function: calmodulin binding; transporter activity; water channel activity; structural constituent of eye lens; glycerol channel activity

Biological Process: lens development in camera-type eye; glycerol transport; cellular water homeostasis; visual perception; canalicular bile acid transport; water transport; response to stimulus; transmembrane transport

Disease: Cataract 15, Multiple Types
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Research Articles on MIP

1. the p.D150H mutation is a novel disease-causing mutation in MIP, which leads to congenital progressive cortical punctate cataract by impairing the trafficking mechanism of AQP0.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MIP antibody

 Products by Pathway  Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Passive Transport By Aquaporins Pathway antibodies  Passive Transport By Aquaporins Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-MIP antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2115 publications with MIP and Inflammation
 Necrosis Antibodies  >1503 publications with MIP and Necrosis
 Immune System Diseases Antibodies  >986 publications with MIP and Immune System Diseases
 Neoplasms Antibodies  >848 publications with MIP and Neoplasms
 Cardiovascular Diseases Antibodies  >801 publications with MIP and Cardiovascular Diseases
 Brain Diseases Antibodies  >472 publications with MIP and Brain Diseases
 Drug Toxicity Antibodies  >347 publications with MIP and Drug Toxicity
 Liver Diseases Antibodies  >257 publications with MIP and Liver Diseases
 Heart Diseases Antibodies  >179 publications with MIP and Heart Diseases
 Kidney Diseases Antibodies  >178 publications with MIP and Kidney Diseases

Organs/Tissues associated with anti-MIP antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >616 publications with MIP and Brain
 Eye Antibodies  >347 publications with MIP and Eye
 Kidney Antibodies  >312 publications with MIP and Kidney
 Adrenal Gland Antibodies  >6 publications with MIP and Adrenal Gland
 Mammary Gland Antibodies  >4 publications with MIP and Mammary Gland
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