• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

MLLT10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3220447

This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. More details

$490 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MLLT10, Polyclonal Antibody
Full Product Name
MLLT10 Antibody - middle region
Product Gene Name
anti-MLLT10 antibody
Product Synonym Gene Name
AF10
Immunogen Sequence
Synthetic peptide located within the following region: KGNKQSKHGP GRPKGNKNQE NVSHLSVSSA SPTSSVASAA GSITSSSLQK
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
MLLT10 peptide (MBS3245248) is used for blocking the activity of MLLT10 antibody (MBS3220447)
Molecular Weight
112 kDa
OMIM
602409
3D Structure
ModBase 3D Structure for P55197
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human MLLT10

Product Categories/Family for anti-MLLT10 antibody

Polyclonal; Transcription Factor; Chromatin & Nuclear Signaling; Disease Related
Applications Tested/Suitable for anti-MLLT10 antibody
Western Blot (WB)

Western Blot (WB) of anti-MLLT10 antibody

Host: Rabbit
Target Name: MLLT10
Sample Tissue: Human Hela Whole Cell lysates
Antibody Dilution: 1ug/ml
Rabbit Anti-MLLT10 Polyclonal Antibody – Cat# MBS3220447

Other Notes

Small volumes of anti-MLLT10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MLLT10 purchase

MBS3220447 is an antibody targeting MLLT10. Also known as MLLT10 Antibody - middle region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MLLT10. It may not necessarily be applicable to this product.

NCBI GI #
307548832
NCBI GeneID
8028
NCBI Accession #
NP_001182555.1
UniProt Primary Accession #
P55197
UniProt Related Accession #
P55197
GenBank Nucleotide #
NM_001195626.1
NCBI Official Full Name
protein AF-10 isoform c
NCBI Official Synonym Full Names
MLLT10 histone lysine methyltransferase DOT1L cofactor
NCBI Official Symbol
MLLT10
NCBI Official Synonym Symbols
AF10
UniProt Protein Name
Protein AF-10
UniProt Synonym Protein Names
ALL1-fused gene from chromosome 10 protein
Protein Family
Protein
UniProt Gene Name
MLLT10
UniProt Synonym Gene Names
AF10
UniProt Entry Name
AF10_HUMAN
NCBI Protein Information
protein AF-10

UniProt Comments for MLLT10

MLLT10: Probably involved in transcriptional regulation. In vitro or as fusion protein with MLL has transactivation activity. Binds to cruciform DNA. A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with MLL/HRX. The result is a rogue activator protein. A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 10p12

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: protein binding; DNA binding; zinc ion binding; transcription factor activity

Biological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter

Disease: Leukemia, Acute Myeloid
Show more

Research Articles on MLLT10

1. In vitro, the overexpression of MLLT10 promoted colorectal cancer (CRC) cell migration and invasion, while after MLLT10 was knocked down, the opposite results were observed. In lung metastasis sites, the knockdown of MLLT10 in SW620 cells significantly inhibited Vimentin expression, whereas the E-Cadherin was increased. These results indicate that MLLT10 regulates the metastasis of CRC cells via EMT.
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MLLT10 antibody

 Reference Product  PubMed Publications
 MLLT3 antibody  >7 publications with MLLT10 and MLLT3
 DOT1L antibody  >7 publications with MLLT10 and DOT1L
 MLLT1 antibody  >5 publications with MLLT10 and MLLT1
 YEATS4 antibody  >2 publications with MLLT10 and YEATS4

Diseases associated with anti-MLLT10 antibody

 Disease Name  Pubmed Publications
 Leukemia, Myeloid, Acute Antibodies  >50 publications with MLLT10 and Leukemia, Myeloid, Acute
 Central Nervous System Diseases Antibodies  >2 publications with MLLT10 and Central Nervous System Diseases
 Meningioma Antibodies  >2 publications with MLLT10 and Meningioma
 Recurrence Antibodies  >1 publications with MLLT10 and Recurrence
 Brain Diseases Antibodies  >1 publications with MLLT10 and Brain Diseases
 Neoplasm Metastasis Antibodies  >1 publications with MLLT10 and Neoplasm Metastasis

Organs/Tissues associated with anti-MLLT10 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >18 publications with MLLT10 and Bone
 Blood Antibodies  >16 publications with MLLT10 and Blood
 Nerve Antibodies  >5 publications with MLLT10 and Nerve
 Testis Antibodies  >5 publications with MLLT10 and Testis
 Muscle Antibodies  >3 publications with MLLT10 and Muscle
 Brain Antibodies  >3 publications with MLLT10 and Brain
 Prostate Antibodies  >1 publications with MLLT10 and Prostate
 Thymus Antibodies  >1 publications with MLLT10 and Thymus
 Eye Antibodies  >1 publications with MLLT10 and Eye
 Placenta Antibodies  >1 publications with MLLT10 and Placenta
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000