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MLLT10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6461855

MBS6461855 is an antibody targeting MLLT10. Also known as MLLT10, CT (AF10) (Protein AF-10, AF10, ALL1-fused Gene From Chromosome 10 Protein) (FITC). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MLLT10, Polyclonal Antibody
Full Product Name
MLLT10, CT (AF10) (Protein AF-10, AF10, ALL1-fused Gene From Chromosome 10 Protein) (FITC)
Product Gene Name
anti-MLLT10 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Protein G Affinity Chromatography.
Specificity
Recognizes human MLLT10.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
109.026
OMIM
602409
3D Structure
ModBase 3D Structure for P55197
Immunogen
Synthetic peptide selected from the C-terminal region of human MLLT10 (KLH).
Conjugate
FITC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-MLLT10 antibody

Antibodies; Disease Markers
Applications Tested/Suitable for anti-MLLT10 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-MLLT10 antibody
IHC: 1:10-1:50
FLISA: 1:1,000
WB: 1:100-1:500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-MLLT10 antibody

Western blot analysis of anti-MLLT10 Pab in Jurkat cell line lysate. MLLT10(arrow) was detected using the purified Pab.
Rabbit Anti-MLLT10 Polyclonal Antibody – Cat# MBS6461855

Immunohistochemistry (IHC) of anti-MLLT10 antibody

Formalin-fixed and paraffin-embedded human testis tissue reacted with MLLT10 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-MLLT10 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6461855

Product References and Citations for anti-MLLT10 antibody

1. Perrin, L., et al., Mol. Cell. Biol. 23(1):119-130 (2003). 2. Nakamura, T., et al., Mol. Cell 10(5):1119-1128 (2002). 3. Roll, P., et al., Cancer Genet. Cytogenet. 135(2):187-191 (2002). 4. Chaplin, T., et al., Blood 85(6):1435-1441 (1995).

Other Notes

Small volumes of anti-MLLT10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MLLT10. It may not necessarily be applicable to this product.

NCBI GI #
4757726
NCBI Accession #
NP_004632
UniProt Primary Accession #
P55197
GenBank Nucleotide #
NP_004632.1
NCBI Official Full Name
protein AF-10 isoform a
UniProt Protein Name
Protein AF-10
UniProt Synonym Protein Names
ALL1-fused gene from chromosome 10 protein
Protein Family
Protein
UniProt Gene Name
MLLT10
UniProt Synonym Gene Names
AF10
UniProt Entry Name
AF10_HUMAN

UniProt Comments for MLLT10

MLLT10: Probably involved in transcriptional regulation. In vitro or as fusion protein with MLL has transactivation activity. Binds to cruciform DNA. A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with MLL/HRX. The result is a rogue activator protein. A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 10p12

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: protein binding; DNA binding; zinc ion binding; transcription factor activity

Biological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter

Disease: Leukemia, Acute Myeloid
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MLLT10 antibody

 Reference Product  PubMed Publications
 MLLT3 antibody  >7 publications with MLLT10 and MLLT3
 DOT1L antibody  >7 publications with MLLT10 and DOT1L
 MLLT1 antibody  >5 publications with MLLT10 and MLLT1
 YEATS4 antibody  >3 publications with MLLT10 and YEATS4

Diseases associated with anti-MLLT10 antibody

 Disease Name  Pubmed Publications
 Leukemia, Myeloid, Acute Antibodies  >51 publications with MLLT10 and Leukemia, Myeloid, Acute
 Central Nervous System Diseases Antibodies  >2 publications with MLLT10 and Central Nervous System Diseases
 Meningioma Antibodies  >2 publications with MLLT10 and Meningioma
 Recurrence Antibodies  >1 publications with MLLT10 and Recurrence
 Brain Diseases Antibodies  >1 publications with MLLT10 and Brain Diseases
 Neoplasm Metastasis Antibodies  >1 publications with MLLT10 and Neoplasm Metastasis

Organs/Tissues associated with anti-MLLT10 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >19 publications with MLLT10 and Bone
 Blood Antibodies  >16 publications with MLLT10 and Blood
 Nerve Antibodies  >5 publications with MLLT10 and Nerve
 Testis Antibodies  >5 publications with MLLT10 and Testis
 Muscle Antibodies  >3 publications with MLLT10 and Muscle
 Brain Antibodies  >3 publications with MLLT10 and Brain
 Prostate Antibodies  >1 publications with MLLT10 and Prostate
 Thymus Antibodies  >1 publications with MLLT10 and Thymus
 Eye Antibodies  >1 publications with MLLT10 and Eye
 Placenta Antibodies  >1 publications with MLLT10 and Placenta
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