Rabbit Anti-MMP14 Polyclonal Antibody – Cat# MBS6321343

MMP14 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the MMP14 antibody detected the MMP14 protein (arrow).

MMP14 Antibody – Rabbit Polyclonal

Name: MMP14 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6321343
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6321343

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MMP14, Polyclonal Antibody

Full Product Name

MMP14, CT (MMP14, Matrix metalloproteinase-14, MMP-X1, Membrane-type matrix metalloproteinase 1, Membrane-type-1 matrix metalloproteinase) (Azide free) (HRP)

Product Gene Name

anti-MMP14 antibody

Product Synonym Names

MMP14; Matrix metalloproteinase-14; MMP-X1; Membrane-type matrix metalloproteinase 1; Membrane-type-1 matrix metalloproteinase

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

65,894 Da

Chromosome Location

Chromosome: 14; NC_000014.8 (23305793..23316803). Location: 14q11-q12

OMIM

600754

3D Structure

ModBase 3D Structure for P50281

Immunogen

MMP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 495-523 amino acids from the C-terminal region of human MMP14.

Conjugate

HRP

Note

Preservative Free

Product Categories/Family for anti-MMP14 antibody

Antibodies; Matrix Metalloproteinases

Applications Tested/Suitable for anti-MMP14 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-MMP14 antibody

WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-MMP14 antibody

Sakr, M.A., et al. Cancer Sci. 101(11):2368-2374(2010). Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010): Chun, T.H., et al. Diabetes 59(10):2484-2494(2010). Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010): Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010).

Other Notes

Small volumes of anti-MMP14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MMP14 purchase

MBS6321343 is an antibody targeting MMP14. Also known as MMP14, CT (MMP14, Matrix metalloproteinase-14, MMP-X1, Membrane-type matrix metalloproteinase 1, Membrane-type-1 matrix metalloproteinase) (Azide free) (HRP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP14. It may not necessarily be applicable to this product.

NCBI GI #

4826834

NCBI GeneID

4323

NCBI Accession #

NP_004986.1

UniProt Primary Accession #

P50281

UniProt Secondary Accession #

Q6GSF3; Q92678; A8K5L0

UniProt Related Accession #

P50281

GenBank Nucleotide #

NM_004995.2

NCBI Official Full Name

matrix metalloproteinase-14 preproprotein

NCBI Official Synonym Full Names

matrix metallopeptidase 14 (membrane-inserted)

NCBI Official Symbol

MMP14

NCBI Official Synonym Symbols

1; MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; MT1-MMP; MT-MMP 1

UniProt Protein Name

Matrix metalloproteinase-14

UniProt Synonym Protein Names

MMP-X1; Membrane-type matrix metalloproteinase 1; MT-MMP 1; MTMMP1; Membrane-type-1 matrix metalloproteinase

Protein Family

Matrix metalloproteinase

UniProt Gene Name

MMP14

UniProt Synonym Gene Names

MMP-14; MT-MMP 1; MTMMP1; MT1-MMP; MT1MMP

UniProt Entry Name

MMP14_HUMAN

NCBI Protein Information

matrix metalloproteinase-14; membrane type 1 metalloprotease; membrane-type matrix metalloproteinase 1; membrane-type-1 matrix metalloproteinase; matrix metalloproteinase 14 (membrane-inserted)

UniProt Comments for MMP14

MMP14: Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Up-regulated by NANOS1. Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. Belongs to the peptidase M10A family.

Protein type: Protease; EC 3.4.24.80; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: extracellular matrix; focal adhesion; integral to plasma membrane; Golgi lumen; cytoplasm; melanosome; plasma membrane

Molecular Function: integrin binding; protein binding; protease activator activity; zinc ion binding; metalloendopeptidase activity; calcium ion binding; transcription factor activity

Biological Process: extracellular matrix organization and biogenesis; tissue remodeling; male gonad development; negative regulation of focal adhesion formation; embryonic cranial skeleton morphogenesis; proteolysis; positive regulation of cell growth; collagen catabolic process; extracellular matrix disassembly; branching morphogenesis of a tube; regulation of transcription, DNA-dependent; ovarian follicle development; response to mechanical stimulus; response to estrogen stimulus; endothelial cell proliferation; response to hypoxia; zymogen activation; angiogenesis; response to oxidative stress; astrocyte cell migration; lung development; endochondral ossification; positive regulation of cell migration

Disease: Winchester Syndrome

Research Articles on MMP14

1. Methyl jasmonate attenuates MMP-14 expression via decreasing the Sp1 expression and binding on MMP-14 promoter, thus inhibiting the migration, invasion and angiogenesis of gastric cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MMP14 antibody

Reference Product	PubMed Publications
MMP2 antibody	>118 publications with MMP14 and MMP2
MMP13 antibody	>45 publications with MMP14 and MMP13
TIMP2 antibody	>26 publications with MMP14 and TIMP2
TIMP3 antibody	>10 publications with MMP14 and TIMP3
TIMP4 antibody	>5 publications with MMP14 and TIMP4
CLDN1 antibody	>3 publications with MMP14 and CLDN1
LRP1 antibody	>2 publications with MMP14 and LRP1
CCL7 antibody	>2 publications with MMP14 and CCL7
CAV1 antibody	>2 publications with MMP14 and CAV1
ACAN antibody	>1 publications with MMP14 and ACAN

Pathways associated with anti-MMP14 antibody

Products by Pathway	Pathway Diagram
AGE/RAGE Pathway antibodies	AGE/RAGE Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Degradation Of Collagen Pathway antibodies	Degradation Of Collagen Pathway Diagram
Degradation Of Collagen Pathway antibodies	Degradation Of Collagen Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
GnRH Signaling Pathway antibodies	GnRH Signaling Pathway Diagram
GnRH Signaling Pathway antibodies	GnRH Signaling Pathway Diagram

Diseases associated with anti-MMP14 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>231 publications with MMP14 and Neoplasms
Neoplasm Invasiveness Antibodies	>95 publications with MMP14 and Neoplasm Invasiveness
Neoplasm Metastasis Antibodies	>73 publications with MMP14 and Neoplasm Metastasis
Breast Neoplasms Antibodies	>51 publications with MMP14 and Breast Neoplasms
Adenocarcinoma Antibodies	>43 publications with MMP14 and Adenocarcinoma
Cardiovascular Diseases Antibodies	>31 publications with MMP14 and Cardiovascular Diseases
Inflammation Antibodies	>30 publications with MMP14 and Inflammation
Lung Neoplasms Antibodies	>21 publications with MMP14 and Lung Neoplasms
Fibrosis Antibodies	>18 publications with MMP14 and Fibrosis
Liver Neoplasms Antibodies	>18 publications with MMP14 and Liver Neoplasms

Organs/Tissues associated with anti-MMP14 antibody

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>84 publications with MMP14 and Vascular
Blood Antibodies	>77 publications with MMP14 and Blood
Bone Antibodies	>54 publications with MMP14 and Bone
Lung Antibodies	>46 publications with MMP14 and Lung
Muscle Antibodies	>38 publications with MMP14 and Muscle
Embryonic Tissue Antibodies	>31 publications with MMP14 and Embryonic Tissue
Connective Tissue Antibodies	>29 publications with MMP14 and Connective Tissue
Brain Antibodies	>24 publications with MMP14 and Brain
Skin Antibodies	>21 publications with MMP14 and Skin
Mouth Antibodies	>20 publications with MMP14 and Mouth