MMS19 Antibody – Rabbit Polyclonal

MMS19: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery. Belongs to the MET18/MMS19 family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 10q24.1

Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; nucleus; spindle

Molecular Function: estrogen receptor binding; protein binding; transcription coactivator activity

Biological Process: chromosome segregation; DNA metabolic process; DNA repair; iron-sulfur cluster assembly; nucleotide-excision repair; positive regulation of transcription, DNA-dependent; response to DNA damage stimulus