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MRPL41 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9430817

MBS9430817 is an antibody targeting MRPL41. Also known as MRPL41 Antibody. Reactive in Human. Host: Rabbit. More details

$325 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MRPL41, Polyclonal Antibody
Full Product Name
MRPL41 Antibody
Product Gene Name
anti-MRPL41 antibody
Product Synonym Names
BMRP; MRPL27; RPML27; 39S ribosomal protein L41; mitochondrial; L41mt; MRP-L41; 39S ribosomal protein L27 homolog; Bcl-2-interacting mitochondrial ribosomal protein L41; Cell proliferation-inducing gene 3 protein; MRP-L27 homolog
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Purity/Purification
Immunogen affinity chromatography
Concentration
1 mg/mL (lot specific)
Specificity
Recognizes endogenous levels of MRPL41 protein.
Preparation and Storage
Store at -20 degree C.
Molecular Weight
21 kDa
3D Structure
ModBase 3D Structure for Q8IXM3
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MRPL41.

Product Categories/Family for anti-MRPL41 antibody

Total protein Ab
Applications Tested/Suitable for anti-MRPL41 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-MRPL41 antibody
WB: 1:500-1:1000
IHC: 1:50-1:100

Western Blot (WB) of anti-MRPL41 antibody

Western blot analysis of MED13L expression in HEK293T, COS7, C6, MEF whole cell lysates.
Rabbit Anti-MRPL41 Polyclonal Antibody – Cat# MBS9430817

Immunohistochemistry (IHC) of anti-MRPL41 antibody

Immunohistochemical analysis of MRPL41 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-MRPL41 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9430817

Other Notes

Small volumes of anti-MRPL41 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MRPL41. It may not necessarily be applicable to this product.

NCBI GI #
21265093
NCBI GeneID
64975
NCBI Accession #
NP_115866.1
UniProt Primary Accession #
Q8IXM3
UniProt Secondary Accession #
Q96Q49
UniProt Related Accession #
Q8IXM3
GenBank Nucleotide #
NM_032477.3
NCBI Official Full Name
39S ribosomal protein L41, mitochondrial
NCBI Official Synonym Full Names
mitochondrial ribosomal protein L41
NCBI Official Symbol
MRPL41
NCBI Official Synonym Symbols
BMRP; PIG3; MRPL27; RPML27; MRP-L27
UniProt Protein Name
39S ribosomal protein L41, mitochondrial
UniProt Synonym Protein Names
39S ribosomal protein L27 homolog; Bcl-2-interacting mitochondrial ribosomal protein L41; Cell proliferation-inducing gene 3 protein; MRP-L27 homolog; Mitochondrial large ribosomal subunit protein mL41
Protein Family
39S ribosomal protein
UniProt Gene Name
MRPL41
UniProt Synonym Gene Names
BMRP; MRPL27; RPML27; L41mt; MRP-L41
NCBI Protein Information
39S ribosomal protein L41, mitochondrial

NCBI Summary for MRPL41

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008]
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UniProt Comments for MRPL41

Component of the mitochondrial ribosome large subunit (PubMed:28892042, PubMed:25838379, PubMed:25278503). Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed:16024796).
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Research Articles on MRPL41

1. Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor status in breast cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-MRPL41 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with MRPL41 and Blood
 Embryonic Tissue Antibodies  >1 publications with MRPL41 and Embryonic Tissue
 Ovary Antibodies  >1 publications with MRPL41 and Ovary
 Lung Antibodies  >1 publications with MRPL41 and Lung
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