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MS4A1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6322378

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
MS4A1, Polyclonal Antibody
Full Product Name
MS4A1, CT (MS4A1, CD20, B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, CD20) (MaxLight 405)
Product Gene Name
anti-MS4A1 antibody
Product Synonym Names
MS4A1; CD20; B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD20
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human MS4A1.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
33077 MW
OMIM
gene 613495
3D Structure
ModBase 3D Structure for P11836
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 216-244 in the C-terminal region of human MS4A1, UniProt Accession #P11836.
Conjugate
MaxLight405
Note
Preservative Free

Product Categories/Family for anti-MS4A1 antibody

Antibodies; CD Markers
Applications Tested/Suitable for anti-MS4A1 antibody
Western Blot (WB), FLISA
Application Notes for anti-MS4A1 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-MS4A1 antibody

Western Blot analysis in HL-60 cell line lysates (35ug/lane) usingMBS6012088. This demonstrates that MBS6012088 detected the MS4A1 protein (arrow).
Rabbit Anti-MS4A1 Polyclonal Antibody – Cat# MBS6322378

Western Blot (WB) of anti-MS4A1 antibody

Western Blot analysis in 293 cell lysates (2ug/lane) usingMBS6012088. Lane 1: Nontransfected Lane 2: Transiently transfected with the MS4A1 gene.
Rabbit Anti-MS4A1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6322378

Product References and Citations for anti-MS4A1 antibody

1. Weber, M.S., et al. Ann. Neurol. 68(3):369-383(2010). 2. Wu, D., et al. Am. J. Clin. Pathol. 134(2):258-265(2010). 3. de Haij, S., et al. Cancer Res. 70(8):3209-3217(2010). 4. Beers, S.A., et al. Semin. Hematol. 47(2):107-114(2010). 5. Davila, S., et al. Genes Immun. 11(3):232-238(2010).

Other Notes

Small volumes of anti-MS4A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MS4A1 purchase

MBS6322378 is an antibody targeting MS4A1. Also known as MS4A1, CT (MS4A1, CD20, B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, CD20) (MaxLight 405). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MS4A1. It may not necessarily be applicable to this product.

NCBI GI #
23110987
NCBI GeneID
931
NCBI Accession #
NP_068769.2
NCBI Related Accession #
NP_690605.1
UniProt Primary Accession #
P11836
UniProt Secondary Accession #
P08984; Q13963; A6NMS4; B4DT24
UniProt Related Accession #
P11836
GenBank Nucleotide #
NM_021950.3
NCBI Official Full Name
B-lymphocyte antigen CD20
NCBI Official Synonym Full Names
membrane spanning 4-domains A1
NCBI Official Symbol
MS4A1
NCBI Official Synonym Symbols
B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16
UniProt Protein Name
B-lymphocyte antigen CD20
UniProt Synonym Protein Names
B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD_antigen: CD20
Protein Family
B-lymphocyte antigen
UniProt Gene Name
MS4A1
UniProt Synonym Gene Names
CD20
UniProt Entry Name
CD20_HUMAN
NCBI Protein Information
B-lymphocyte antigen CD20

UniProt Comments for MS4A1

MS4A1: This protein may be involved in the regulation of B-cell activation and proliferation. Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the MS4A family.

Protein type: Membrane protein, integral; Cell surface; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: extracellular space; integral to plasma membrane; external side of plasma membrane

Molecular Function: epidermal growth factor receptor binding

Biological Process: B cell proliferation; humoral immune response

Disease: Immunodeficiency, Common Variable, 5
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Research Articles on MS4A1

1. Limiting the antibody-induced induction of immunosuppressive reactive oxygen species may improve the anti-leukemic efficacy of anti-CD20 therapy in chronic lymphocytic leukemia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MS4A1 antibody

 Reference Product  PubMed Publications
 CD19 antibody  >918 publications with MS4A1 and CD19
 CD22 antibody  >352 publications with MS4A1 and CD22
 CD79A antibody  >302 publications with MS4A1 and CD79A
 CD40 antibody  >174 publications with MS4A1 and CD40
 CD79B antibody  >165 publications with MS4A1 and CD79B
 POU2AF1 antibody  >7 publications with MS4A1 and POU2AF1
 LYN antibody  >4 publications with MS4A1 and LYN
 LCK antibody  >4 publications with MS4A1 and LCK

Pathways associated with anti-MS4A1 antibody

 Products by Pathway  Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with anti-MS4A1 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >365 publications with MS4A1 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >303 publications with MS4A1 and Neoplasms, Experimental
 Respiratory Tract Diseases Antibodies  >298 publications with MS4A1 and Respiratory Tract Diseases
 Inflammation Antibodies  >287 publications with MS4A1 and Inflammation
 Necrosis Antibodies  >245 publications with MS4A1 and Necrosis
 Carcinoma Antibodies  >196 publications with MS4A1 and Carcinoma
 Skin Neoplasms Antibodies  >181 publications with MS4A1 and Skin Neoplasms
 Chromosome Aberrations Antibodies  >180 publications with MS4A1 and Chromosome Aberrations
 Lung Diseases Antibodies  >165 publications with MS4A1 and Lung Diseases
 Hyperplasia Antibodies  >146 publications with MS4A1 and Hyperplasia

Organs/Tissues associated with anti-MS4A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3184 publications with MS4A1 and Blood
 Lymph Node Antibodies  >525 publications with MS4A1 and Lymph Node
 Lymph Antibodies  >501 publications with MS4A1 and Lymph
 Skin Antibodies  >341 publications with MS4A1 and Skin
 Kidney Antibodies  >277 publications with MS4A1 and Kidney
 Spleen Antibodies  >219 publications with MS4A1 and Spleen
 Vascular Antibodies  >212 publications with MS4A1 and Vascular
 Lung Antibodies  >187 publications with MS4A1 and Lung
 Brain Antibodies  >108 publications with MS4A1 and Brain
 Stomach Antibodies  >88 publications with MS4A1 and Stomach
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