MSH3 Antibody – Rabbit Polyclonal

The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]

MSH3: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion- deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Defects in MSH3 are a cause of susceptibility to endometrial cancer (ENDMC). Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 5q11-q12

Cellular Component: nucleoplasm; nuclear chromosome; membrane; nucleus; MutSbeta complex

Molecular Function: DNA-dependent ATPase activity; double-strand/single-strand DNA junction binding; protein homodimerization activity; dinucleotide repeat insertion binding; oxidized purine DNA binding; mismatched DNA binding; loop DNA binding; Y-form DNA binding; centromeric DNA binding; protein binding; enzyme binding; single guanine insertion binding; guanine/thymine mispair binding; dinucleotide insertion or deletion binding; ATP binding; single-stranded DNA binding

Biological Process: positive regulation of helicase activity; negative regulation of DNA recombination; mismatch repair; meiotic recombination; somatic recombination of immunoglobulin gene segments; DNA repair; maintenance of DNA repeat elements; meiotic mismatch repair

Disease: Endometrial Cancer