Rabbit Anti-MSK1 Polyclonal Antibody – Cat# MBS6488614

MSK1 Antibody – Rabbit Polyclonal

Name: MSK1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6488614
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6488614

MBS6488614 is an antibody targeting MSK1. Also known as MSK1, Phosphorylated (Ser360) (Ribosomal Protein S6 Kinase alpha 5, Nuclear Mitogen-and Stress-activated Protein Kinase 1, 90kD Ribosomal Protein S6 Kinase 5, RSK-like Protein Kinase, RLSK, S6K-alpha-5,… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MSK1, Polyclonal Antibody

Full Product Name

MSK1, Phosphorylated (Ser360) (Ribosomal Protein S6 Kinase alpha 5, Nuclear Mitogen-and Stress-activated Protein Kinase 1, 90kD Ribosomal Protein S6 Kinase 5, RSK-like Protein Kinase, RLSK, S6K-alpha-5, RPS6KA5, MSK) (Azide free) (HRP)

Product Gene Name

anti-MSK1 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

Purity/Purification

Purified by Immunoaffinity chromatography.

Specificity

Recognizes human MSK1 when phosphorylated at Ser360.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

89.865

OMIM

603607

3D Structure

ModBase 3D Structure for O75582

Immunogen

Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser360 of human MSK1 (KLH).

Conjugate

HRP

Antigen Modification

Phosphorylated

Note

Preservative Free

Product Categories/Family for anti-MSK1 antibody

Antibodies; Protein Kinases; Ribosomal

Applications Tested/Suitable for anti-MSK1 antibody

Immunohistochemistry (IHC), ELISA (EIA)

Application Notes for anti-MSK1 antibody

IHC: 1:50-1:100
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-MSK1 antibody

1. Beausoleil, S.A., et al., Proc. Natl. Acad. Sci. USA 101(33):12130-12135 (2004). 2. Abecassis, L., et al., J. Biol. Chem. 279(29):30474-30479 (2004). 3. Zhang, Y., et al., Carcinogenesis 25(7):1165-1175 (2004). 4. Zhang, Y., et al., J. Biol. Chem. 279(21):21866-21872 (2004). 5. Li, Y., et al., J. Biol. Chem. 279(2):970-979 (2004).

Other Notes

Small volumes of anti-MSK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MSK1. It may not necessarily be applicable to this product.

NCBI GI #

32528295

NCBI GeneID

9252

NCBI Accession #

NP_004746

UniProt Primary Accession #

O75582

UniProt Related Accession #

O75582

GenBank Nucleotide #

NP_004746.2

NCBI Official Full Name

ribosomal protein S6 kinase alpha-5 isoform a

NCBI Official Synonym Full Names

ribosomal protein S6 kinase A5

NCBI Official Symbol

RPS6KA5

NCBI Official Synonym Symbols

MSK1; RLPK; MSPK1

UniProt Protein Name

Ribosomal protein S6 kinase alpha-5

UniProt Synonym Protein Names

90 kDa ribosomal protein S6 kinase 5; Nuclear mitogen- and stress-activated protein kinase 1; RSK-like protein kinase

UniProt Gene Name

RPS6KA5

UniProt Synonym Gene Names

MSK1; S6K-alpha-5; RSKL

UniProt Entry Name

KS6A5_HUMAN

NCBI Protein Information

ribosomal protein S6 kinase alpha-5

UniProt Comments for MSK1

MSK1: an AGC kinase of the RSK family. Has two kinase domains connected by a regulatory linker region. Enzyme activity requires the presence of both kinase domains. Is phosphorylated and activated by Erk as well as p38 MAPK in response to growth factors and cellular stress.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, AGC; AGC group; RSK family; MSK subfamily

Chromosomal Location of Human Ortholog: 14q31-q32.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding; protein kinase activity

Biological Process: axon guidance; nerve growth factor receptor signaling pathway; positive regulation of histone phosphorylation; histone phosphorylation; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; regulation of transcription, DNA-dependent; inflammatory response; toll-like receptor 4 signaling pathway; epidermal growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; activation of CREB transcription factor; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; negative regulation of cytokine production; toll-like receptor signaling pathway; innate immune response; positive regulation of histone acetylation; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; negative regulation of transcription, DNA-dependent

Research Articles on MSK1

1. show that expression of nuclear PKCdelta activates ERK and MSK1, that ERK activation is required for MSK1 activation, and that both ERK and MSK1 activation are required for apoptosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MSK1 antibody

Reference Product	PubMed Publications
BAD antibody	>1 publications with MSK1 and BAD

Pathways associated with anti-MSK1 antibody

Products by Pathway	Pathway Diagram
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CREB Phosphorylation Pathway antibodies	CREB Phosphorylation Pathway Diagram
Circadian Entrainment Pathway antibodies	Circadian Entrainment Pathway Diagram
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Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
EGFR1 Signaling Pathway antibodies	EGFR1 Signaling Pathway Diagram

Organs/Tissues associated with anti-MSK1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2 publications with MSK1 and Brain