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MSL3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6322547

This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females.… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
MSL3, Polyclonal Antibody
Full Product Name
MSL3, NT (MSL3, MSL3L1, Male-specific lethal 3 homolog, Male-specific lethal-3 homolog 1, Male-specific lethal-3 protein-like 1) (MaxLight 750)
Product Gene Name
anti-MSL3 antibody
Product Synonym Names
MSL3; MSL3L1; Male-specific lethal 3 homolog; Male-specific lethal-3 homolog 1; Male-specific lethal-3 protein-like 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
59,824 Da
OMIM
300609
3D Structure
ModBase 3D Structure for Q8N5Y2
Immunogen
MSL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-55 amino acids from the N-terminal region of human MSL3.
Conjugate
MaxLight750
Note
Preservative Free

Product Categories/Family for anti-MSL3 antibody

Antibodies; Transcription Factors
Applications Tested/Suitable for anti-MSL3 antibody
Western Blot (WB), FLISA
Application Notes for anti-MSL3 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-MSL3 antibody

Smith, E.R., et al. Mol. Cell. Biol. 25(21):9175-9188(2005). Marin, I., et al. Mol. Biol. Evol. 17(8):1240-1250(2000). Prakash, S.K., et al. Genomics 59(1):77-84(1999).

Other Notes

Small volumes of anti-MSL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MSL3 purchase

MBS6322547 is an antibody targeting MSL3. Also known as MSL3, NT (MSL3, MSL3L1, Male-specific lethal 3 homolog, Male-specific lethal-3 homolog 1, Male-specific lethal-3 protein-like 1) (MaxLight 750). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MSL3. It may not necessarily be applicable to this product.

NCBI GI #
300796021
NCBI GeneID
10943
NCBI Accession #
NP_001180199.1
UniProt Primary Accession #
Q8N5Y2
UniProt Secondary Accession #
Q9UG70; Q9Y5Z8; A6NCU2; A6NHW8; A8K165; B4DUV8; B7Z227
UniProt Related Accession #
Q8N5Y2
GenBank Nucleotide #
NM_001193270.2
NCBI Official Full Name
male-specific lethal 3 homolog isoform e
NCBI Official Synonym Full Names
male-specific lethal 3 homolog (Drosophila)
NCBI Official Symbol
MSL3
NCBI Official Synonym Symbols
MSL3L1
UniProt Protein Name
Male-specific lethal 3 homolog
UniProt Synonym Protein Names
Male-specific lethal-3 homolog 1; Male-specific lethal-3 protein-like 1
Protein Family
Male-specific lethal
UniProt Gene Name
MSL3
UniProt Synonym Gene Names
MSL3L1; MSL3-like 1
UniProt Entry Name
MS3L1_HUMAN
NCBI Protein Information
male-specific lethal 3 homolog; MSL3-like 1; male-specific lethal-3 protein-like 1

UniProt Comments for MSL3

MSL3L1: May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: Xp22.3

Cellular Component: nucleoplasm; nucleus

Molecular Function: DNA binding; transcription factor activity; methylated histone residue binding

Biological Process: transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; multicellular organismal development
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MSL3 antibody

 Reference Product  PubMed Publications
 MSL2 antibody  >12 publications with MSL3 and MSL2
 MSL1 antibody  >12 publications with MSL3 and MSL1

Pathways associated with anti-MSL3 antibody

 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 HATs Acetylate Histones Pathway antibodies  HATs Acetylate Histones Pathway Diagram

Organs/Tissues associated with anti-MSL3 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >2 publications with MSL3 and Embryonic Tissue
 Eye Antibodies  >1 publications with MSL3 and Eye
 Blood Antibodies  >1 publications with MSL3 and Blood
 Intestine Antibodies  >1 publications with MSL3 and Intestine
 Testis Antibodies  >1 publications with MSL3 and Testis
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