MTA1 Antibody – Rabbit Polyclonal

MTA1: metastasis-associated protein. A component of the NuRD ATP-dependent chromatin remodeling and histone deacetylase complex. Interacts with HDAC1. Expressed at high levels in metastatic cells. Two alternatively spliced isoforms have been described. The long isoform is a co-repressor of estrogen receptor (ER). The short isoform binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q32.3

Cellular Component: nucleoplasm; microtubule; intracellular membrane-bound organelle; cytoplasm; nuclear envelope; NuRD complex; nucleus

Molecular Function: protein binding; zinc ion binding; transcription coactivator activity; chromatin binding; transcription factor activity; transcription corepressor activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; locomotor rhythm; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of transcription, DNA-dependent; double-strand break repair; regulation of inflammatory response; response to lipopolysaccharide; circadian regulation of gene expression; response to ionizing radiation; signal transduction; regulation of gene expression, epigenetic; entrainment of circadian clock by photoperiod