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MTMR14 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6322803

This gene encodes a myotubularin-related protein. The encoded protein is a phosphoinositide phosphatase that specifically dephosphorylates phosphatidylinositol 3,5-biphosphate and phosphatidylinositol 3-phosphate. Mutations in this gene are correlated with… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
MTMR14, Polyclonal Antibody
Full Product Name
MTMR14, NT (MTMR14, C3orf29, Myotubularin-related protein 14, HCV NS5A-transactivated protein 4 splice variant A-binding protein 1, hJumpy) (APC)
Product Gene Name
anti-MTMR14 antibody
Product Synonym Names
MTMR14; C3orf29; Myotubularin-related protein 14; HCV NS5A-transactivated protein 4 splice variant A-binding protein 1; hJumpy
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
72,203 Da
OMIM
160150
3D Structure
ModBase 3D Structure for Q8NCE2
Immunogen
MTMR14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of human MTMR14.
Conjugate
APC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-MTMR14 antibody

Antibodies; Binding Proteins
Applications Tested/Suitable for anti-MTMR14 antibody
Western Blot (WB), FLISA
Application Notes for anti-MTMR14 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-MTMR14 antibody

MTMR14 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the MTMR14 antibody detected the MTMR14 protein (arrow).
Rabbit Anti-MTMR14 Polyclonal Antibody – Cat# MBS6322803

Product References and Citations for anti-MTMR14 antibody

Gibbs, E.M., et al. Autophagy 6(6):819-820(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Vergne, I., et al. EMBO J. 28(15):2244-2258(2009). Tosch, V., et al. Hum. Mol. Genet. 15(21):3098-3106(2006).

Other Notes

Small volumes of anti-MTMR14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MTMR14 purchase

MBS6322803 is an antibody targeting MTMR14. Also known as MTMR14, NT (MTMR14, C3orf29, Myotubularin-related protein 14, HCV NS5A-transactivated protein 4 splice variant A-binding protein 1, hJumpy) (APC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MTMR14. It may not necessarily be applicable to this product.

NCBI GI #
117938270
NCBI GeneID
64419
NCBI Accession #
NP_001070993.1
NCBI Related Accession #
NP_001070994.1
UniProt Primary Accession #
Q8NCE2
UniProt Secondary Accession #
Q0JTH5; Q0JU83; Q6PIZ4; Q6QE21; Q86VK9; Q8IYK1; Q8TCM7; Q9H6C0
UniProt Related Accession #
Q8NCE2
GenBank Nucleotide #
NM_001077525.2
NCBI Official Full Name
myotubularin-related protein 14 isoform 2
NCBI Official Synonym Full Names
myotubularin related protein 14
NCBI Official Symbol
MTMR14
NCBI Official Synonym Symbols
C3orf29
UniProt Protein Name
Myotubularin-related protein 14
UniProt Synonym Protein Names
HCV NS5A-transactivated protein 4 splice variant A-binding protein 1; NS5ATP4ABP1; hJumpy
Protein Family
Myotubularin-related protein
UniProt Gene Name
MTMR14
UniProt Synonym Gene Names
C3orf29; NS5ATP4ABP1
UniProt Entry Name
MTMRE_HUMAN
NCBI Protein Information
myotubularin-related protein 14; jumpy; NS5ATP4ABP1; egg-derived tyrosine phosphatase homolog; HCV NS5A-transactivated protein 4 splice variant A-binding protein 1

UniProt Comments for MTMR14

MTMR14: Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.-; Phosphatase, lipid

Chromosomal Location of Human Ortholog: 3p26

Cellular Component: ruffle; perinuclear region of cytoplasm; cytosol

Molecular Function: phosphatidylinositol-3-phosphatase activity; protein tyrosine phosphatase activity

Biological Process: phospholipid metabolic process; phosphatidylinositol biosynthetic process

Disease: Myopathy, Centronuclear, 1
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MTMR14 antibody

 Products by Pathway  Pathway Diagram
 3-phosphoinositide Degradation Pathway antibodies  3-phosphoinositide Degradation Pathway Diagram
 3-phosphoinositide Degradation Pathway antibodies  3-phosphoinositide Degradation Pathway Diagram
 D-myo-inositol-5-phosphate Metabolism Pathway antibodies  D-myo-inositol-5-phosphate Metabolism Pathway Diagram
 D-myo-inositol-5-phosphate Metabolism Pathway antibodies  D-myo-inositol-5-phosphate Metabolism Pathway Diagram
 Superpathway Of Inositol Phosphate Compounds antibodies  Superpathway Of Inositol Phosphate Compounds Diagram

Diseases associated with anti-MTMR14 antibody

 Disease Name  Pubmed Publications
 MYOPATHY, CENTRONUCLEAR, 1 Antibodies  >4 publications with MTMR14 and MYOPATHY, CENTRONUCLEAR, 1
 Neurologic Manifestations Antibodies  >3 publications with MTMR14 and Neurologic Manifestations
 Congenital Abnormalities Antibodies  >3 publications with MTMR14 and Congenital Abnormalities
 Disease Models, Animal Antibodies  >2 publications with MTMR14 and Disease Models, Animal
 Heart Defects, Congenital Antibodies  >1 publications with MTMR14 and Heart Defects, Congenital
 Chromosome Aberrations Antibodies  >1 publications with MTMR14 and Chromosome Aberrations
 Abnormalities, Multiple Antibodies  >1 publications with MTMR14 and Abnormalities, Multiple

Organs/Tissues associated with anti-MTMR14 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >11 publications with MTMR14 and Muscle
 Heart Antibodies  >4 publications with MTMR14 and Heart
 Lung Antibodies  >1 publications with MTMR14 and Lung
 Embryonic Tissue Antibodies  >1 publications with MTMR14 and Embryonic Tissue
 Blood Antibodies  >1 publications with MTMR14 and Blood
 Brain Antibodies  >1 publications with MTMR14 and Brain
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