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MTTP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9231996

Description: Purified Rabbit Polyclonal Antibody (Pab)Background: Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. More details

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Product Overview

Product Name
MTTP, Polyclonal Antibody
Full Product Name
MTTP Antibody (C-term)
Product Gene Name
anti-MTTP antibody
Product Synonym Names
Microsomal triglyceride transfer protein large subunit; MTTP; MTP
Clonality
Polyclonal
Isotype
Ig
Host
Rabbit
Species Reactivity
Human
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Specificity
This MTTP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 878-911 amino acids from the C-terminal region of human MTTP.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
99351
OMIM
gene 200100
3D Structure
ModBase 3D Structure for P55157
Antigen Source
Human
Antigen Region
878-911
Antigen Type
Synthetic Peptide
Applications Tested/Suitable for anti-MTTP antibody
Western Blot (WB), Flow Cytometry (FC/FACS), ELISA (EIA)
Application Notes for anti-MTTP antibody
WB: 1:1000
FC/FACS: 1:25

Western Blot (WB) of anti-MTTP antibody

All lanes : Anti-MTTP Antibody (C-term) at 1:1000 dilution
Lane 1: HepG2 whole cell lysates
Lane 2: human liver lysates

Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution

Predicted band size : 99 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.
Rabbit Anti-MTTP Polyclonal Antibody – Cat# MBS9231996

Flow Cytometry (FC/FACS) of anti-MTTP antibody

Flow cytometric analysis of Hela cells using MTTP Antibody (C-term)(green) compared to an isotype control of rabbit IgG(blue). It was diluted at 1:25 dilution. An Alexa Fluor 488 goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody.
Rabbit Anti-MTTP Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS9231996

Product References and Citations for anti-MTTP antibody

Shoulders C.C.,et al.Hum. Mol. Genet. 2:2109-2116(1993). Sharp D.,et al.Nature 365:65-69(1993). Sharp D.,et al.Biochemistry 33:9057-9061(1994). Ota T.,et al.Nat. Genet. 36:40-45(2004). Hagan D.L.,et al.J. Biol. Chem. 269:28737-28744(1994).

Other Notes

Small volumes of anti-MTTP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MTTP purchase

MBS9231996 is an antibody targeting MTTP. Also known as MTTP Antibody (C-term). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MTTP. It may not necessarily be applicable to this product.

NCBI GI #
1709167
NCBI GeneID
4547
NCBI Accession #
P55157.1
UniProt Primary Accession #
P55157
UniProt Related Accession #
P55157
NCBI Official Full Name
Microsomal triglyceride transfer protein large subunit
NCBI Official Synonym Full Names
microsomal triglyceride transfer protein
NCBI Official Symbol
MTTP
NCBI Official Synonym Symbols
ABL; MTP
UniProt Protein Name
Microsomal triglyceride transfer protein large subunit
Protein Family
Microsomal triglyceride transfer protein
UniProt Gene Name
MTTP
UniProt Synonym Gene Names
MTP
UniProt Entry Name
MTP_HUMAN
NCBI Protein Information
microsomal triglyceride transfer protein large subunit

NCBI Summary for MTTP

MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]
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UniProt Comments for MTTP

MTTP: Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. Defects in MTTP are the cause of abetalipoproteinemia (ABL). ABL is an autosomal recessive disorder of lipoprotein metabolism. Affected individuals produce virtually no circulating apolipoprotein B-containing lipoproteins (chylomicrons, VLDL, LDL, lipoprotein(A)). Malabsorption of the antioxidant vitamin E occurs, leading to spinocerebellar and retinal degeneration.

Protein type: Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: endoplasmic reticulum lumen; receptor complex

Molecular Function: lipid transporter activity; lipid binding

Biological Process: lipoprotein metabolic process; lipid metabolic process; lipid transport

Disease: Abdominal Obesity-metabolic Syndrome 1; Abetalipoproteinemia
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Research Articles on MTTP

1. Intestinal expression of MTP is negatively associated with plasma insulin concentrations and positively associated with plasma glucose concentrations.Duodenal expression of MTP was upregulated in type 2 diabetic patients compared with nondiabetic patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MTTP antibody

 Reference Product  PubMed Publications
 APOB antibody  >47 publications with MTTP and APOB
 FOXO1 antibody  >4 publications with MTTP and FOXO1
 NR2F1 antibody  >2 publications with MTTP and NR2F1
 SAR1B antibody  >2 publications with MTTP and SAR1B
 APOA1 antibody  >2 publications with MTTP and APOA1
 APOA2 antibody  >1 publications with MTTP and APOA2
 APOA4 antibody  >1 publications with MTTP and APOA4

Pathways associated with anti-MTTP antibody

 Products by Pathway  Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Statin Pathway antibodies  Statin Pathway Diagram

Diseases associated with anti-MTTP antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >38 publications with MTTP and Fatty Liver
 Liver Diseases Antibodies  >27 publications with MTTP and Liver Diseases
 Cardiovascular Diseases Antibodies  >17 publications with MTTP and Cardiovascular Diseases
 Dyslipidemias Antibodies  >15 publications with MTTP and Dyslipidemias
 Abetalipoproteinemia Antibodies  >15 publications with MTTP and Abetalipoproteinemia
 Atherosclerosis Antibodies  >13 publications with MTTP and Atherosclerosis
 Inflammation Antibodies  >11 publications with MTTP and Inflammation
 Non-alcoholic Fatty Liver Disease Antibodies  >9 publications with MTTP and Non-alcoholic Fatty Liver Disease
 Insulin Resistance Antibodies  >9 publications with MTTP and Insulin Resistance
 Nervous System Diseases Antibodies  >7 publications with MTTP and Nervous System Diseases

Organs/Tissues associated with anti-MTTP antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >68 publications with MTTP and Liver
 Blood Antibodies  >57 publications with MTTP and Blood
 Intestine Antibodies  >25 publications with MTTP and Intestine
 Vascular Antibodies  >7 publications with MTTP and Vascular
 Brain Antibodies  >7 publications with MTTP and Brain
 Muscle Antibodies  >3 publications with MTTP and Muscle
 Prostate Antibodies  >2 publications with MTTP and Prostate
 Kidney Antibodies  >1 publications with MTTP and Kidney
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