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MVD Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6488724

MBS6488724 is an antibody targeting MVD. Also known as MVD, NT (Mevalonate Pyrophosphate Decarboxylase, MPD, Diphosphomevalonate Decarboxylase, FP17780, Mevalonate (Diphospho) Decarboxylase, MDDase) (HRP). Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MVD, Polyclonal Antibody
Full Product Name
MVD, NT (Mevalonate Pyrophosphate Decarboxylase, MPD, Diphosphomevalonate Decarboxylase, FP17780, Mevalonate (Diphospho) Decarboxylase, MDDase) (HRP)
Product Gene Name
anti-MVD antibody
Product Synonym Names
Mevalonate (Diphospho)Decarboxylase; EC=4.1.1.33
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Ammonium Sulfate Precipitation.
Specificity
Recognizes human MVD.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
Molecular Weight
45.6 kDa (420aa), confirmed by MALDI-TOF
OMIM
603236
3D Structure
ModBase 3D Structure for P53602
Immunogen
Synthetic peptide selected from the N-terminal region of human MVD (KLH).
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-MVD antibody

Antibodies; Enzymes; Decarboxylase
Applications Tested/Suitable for anti-MVD antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-MVD antibody
WB: 1:50-1:100
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-MVD antibody

Western blot analysis of MVD (arrow) using rabbit polyclonal MVD Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MVD gene (Lane 2).
Rabbit Anti-MVD Polyclonal Antibody – Cat# MBS6488724

Immunohistochemistry (IHC) of anti-MVD antibody

Formalin-fixed and paraffin-embedded human Skeletal muscle reacted with MVD Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-MVD Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6488724

Product References and Citations for anti-MVD antibody

1. Voynova, N.E., Arch. Biochem. Biophys. 480(1), 58-67 (2008). 2. Hogenboom, S., Mol. Genet. Metab. 81(3), 216-224 (2004). 3. Wadhwa, R., Biochem. Biophys. Res. Commun. 302(4), 735-742 (2003).

Other Notes

Small volumes of anti-MVD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MVD. It may not necessarily be applicable to this product.

NCBI GI #
4505289
NCBI GeneID
4597
NCBI Accession #
NP_002452
UniProt Primary Accession #
P53602
UniProt Secondary Accession #
Q53Y65
UniProt Related Accession #
P53602
GenBank Nucleotide #
NM_002461.2
NCBI Official Full Name
diphosphomevalonate decarboxylase
NCBI Official Synonym Full Names
mevalonate diphosphate decarboxylase
NCBI Official Symbol
MVD
NCBI Official Synonym Symbols
MPD; MDDase; POROK7; FP17780
UniProt Protein Name
Diphosphomevalonate decarboxylase
UniProt Synonym Protein Names
Mevalonate (diphospho)decarboxylase; MDDase; Mevalonate pyrophosphate decarboxylase
UniProt Gene Name
MVD
UniProt Synonym Gene Names
MPD; MDDase
UniProt Entry Name
MVD1_HUMAN
NCBI Protein Information
diphosphomevalonate decarboxylase

NCBI Summary for MVD

The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]

UniProt Comments for MVD

MVD: Performs the first committed step in the biosynthesis of isoprenes. Belongs to the diphosphomevalonate decarboxylase family.

Protein type: Lyase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 4.1.1.33

Chromosomal Location of Human Ortholog: 16q24.3

Cellular Component: peroxisome; cytosol

Molecular Function: diphosphomevalonate decarboxylase activity; protein homodimerization activity; Hsp70 protein binding; ATP binding

Biological Process: cellular protein metabolic process; isoprenoid biosynthetic process; isopentenyl diphosphate biosynthetic process, mevalonate pathway; dolichol-linked oligosaccharide biosynthetic process; positive regulation of cell proliferation; dolichyl diphosphate biosynthetic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; cholesterol biosynthetic process
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Research Articles on MVD

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MVD antibody

 Reference Product  PubMed Publications
 IDI1 antibody  >4 publications with MVD and IDI1
 FDPS antibody  >3 publications with MVD and FDPS
 HMGCS1 antibody  >1 publications with MVD and HMGCS1

Pathways associated with anti-MVD antibody

 Products by Pathway  Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway antibodies  Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram

Diseases associated with anti-MVD antibody

 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >506 publications with MVD and Neoplasm Metastasis
 Liver Neoplasms Antibodies  >282 publications with MVD and Liver Neoplasms
 Breast Neoplasms Antibodies  >265 publications with MVD and Breast Neoplasms
 Heart Diseases Antibodies  >255 publications with MVD and Heart Diseases
 Pain Antibodies  >255 publications with MVD and Pain
 Liver Diseases Antibodies  >247 publications with MVD and Liver Diseases
 Neoplasms, Experimental Antibodies  >245 publications with MVD and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >228 publications with MVD and Lung Neoplasms
 Disease Models, Animal Antibodies  >214 publications with MVD and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >184 publications with MVD and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-MVD antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >2326 publications with MVD and Vascular
 Blood Antibodies  >2078 publications with MVD and Blood
 Lymph Antibodies  >473 publications with MVD and Lymph
 Lymph Node Antibodies  >452 publications with MVD and Lymph Node
 Nerve Antibodies  >408 publications with MVD and Nerve
 Brain Antibodies  >355 publications with MVD and Brain
 Liver Antibodies  >319 publications with MVD and Liver
 Lung Antibodies  >313 publications with MVD and Lung
 Muscle Antibodies  >305 publications with MVD and Muscle
 Bone Antibodies  >254 publications with MVD and Bone
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