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MYST2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6489240

MBS6489240 is an antibody targeting MYST2. Also known as MYST2, ID (Histone Acetyltransferase MYST2, EC 2.3.1.48, MYST Protein 2, MOZ, YBF2/SAS3, SAS2 and TIP60 Protein 2, Histone Acetyltransferase Binding to ORC1, HBO1, HBOa) (MaxLight 650). Reactive in… More details

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Product Overview

Online Datasheet in PDF
Product Name
MYST2, Polyclonal Antibody
Full Product Name
MYST2, ID (Histone Acetyltransferase MYST2, EC 2.3.1.48, MYST Protein 2, MOZ, YBF2/SAS3, SAS2 and TIP60 Protein 2, Histone Acetyltransferase Binding to ORC1, HBO1, HBOa) (MaxLight 650)
Product Gene Name
anti-MYST2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.
Purity/Purification
Purified by Ammonium Sulfate Precipitation.
Specificity
Recognizes human HBO1.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
71kDa
OMIM
609880
3D Structure
ModBase 3D Structure for O95251
Immunogen
Synthetic peptide selected from the center region of human HBO1/MYST2 (KLH).
Conjugate
MaxLight650
Note
Preservative Free

Product Categories/Family for anti-MYST2 antibody

Antibodies; Enzymes; Acetyltransferase
Applications Tested/Suitable for anti-MYST2 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-MYST2 antibody
IHC: 1:10-1:50
FLISA: 1:1,000
WB: 1:50-1:100
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-MYST2 antibody

HBO1/MYST2 Antibody (Center) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the HBO1/MYST2 antibody detected the HBO1/MYST2 protein (arrow).
Rabbit Anti-MYST2 Polyclonal Antibody – Cat# MBS6489240

Immunohistochemistry (IHC) of anti-MYST2 antibody

Formalin-fixed and paraffin-embedded human testis tissue reacted with HBO1/MYST2 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-MYST2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6489240

Immunofluorescence (IF) of anti-MYST2 antibody

Fluorescent confocal image of Hela cell stained with HBO1/MYST2 Antibody (Center). Hela cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with HBO1/MYST2 primary antibody (1:25, 1 h at 37 degree C). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37 degree C).Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37 degree C). Nuclei were counterstained with DAPI (blue) (10 ug/ml, 10 min). HBO1/MYST2 immunoreactivity is localized to nucleus significantly.
Rabbit Anti-MYST2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS6489240

Product References and Citations for anti-MYST2 antibody

1. Wu, Z.Q., Proc. Natl. Acad. Sci. USA 105(6), 1919-1924 (2008). 2. Iizuka, M., Mol. Cell. Biol. 28(1), 140-153 (2008).

Other Notes

Small volumes of anti-MYST2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MYST2. It may not necessarily be applicable to this product.

NCBI GI #
312434011
NCBI GeneID
11143
NCBI Accession #
NP_008998
UniProt Primary Accession #
O95251
UniProt Related Accession #
O95251
GenBank Nucleotide #
NM_007067
NCBI Official Full Name
histone acetyltransferase KAT7 isoform 2
NCBI Official Synonym Full Names
lysine acetyltransferase 7
NCBI Official Symbol
KAT7
NCBI Official Synonym Symbols
HBO1; HBOA; MYST2; ZC2HC7
UniProt Protein Name
Histone acetyltransferase KAT7
UniProt Synonym Protein Names
Histone acetyltransferase binding to ORC1; Lysine acetyltransferase 7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
UniProt Gene Name
KAT7
UniProt Synonym Gene Names
HBO1; HBOa; MYST2; MYST-2
UniProt Entry Name
KAT7_HUMAN
NCBI Protein Information
histone acetyltransferase KAT7

NCBI Summary for MYST2

The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016]
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UniProt Comments for MYST2

MYST2: a histone acetyltransferase that participates in DNA replication and the loading of the minichromosome maintenance (Mcm) complex onto chromatin. Is required for origin recognition complex (Orc) formation and replication licensing, and is responsible for much of the acetylation of histone H4. Interacts with MCM2 and ORC1L. Phosphorylated by Cdc2 during mitosis, creating a site that recruits Plk1, which in turn phosphorylates MYST2. Its phosphorylation by Plk1 during mitosis may be required for the formation of the prereplicative complex. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone. Specifically represses AR-mediated transcription.

Protein type: EC 2.3.1.48; Transcription, coactivator/corepressor; Acetyltransferase; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: nucleoplasm; cytoplasm; nucleolus; histone acetyltransferase complex

Molecular Function: protein binding; histone acetyltransferase activity; zinc ion binding; transcription factor activity

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of transcription, DNA-dependent; DNA replication
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Research Articles on MYST2

1. results indicate that the N-terminal region of JADE1 functions as a platform that brings together the catalytic HBO1 subunit with its cognate H3-H4 substrate for histone acetylation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MYST2 antibody

 Reference Product  PubMed Publications
 ING4 antibody  >6 publications with MYST2 and ING4
 MCM2 antibody  >4 publications with MYST2 and MCM2
 ORC1 antibody  >2 publications with MYST2 and ORC1
 CDK11A antibody  >1 publications with MYST2 and CDK11A

Pathways associated with anti-MYST2 antibody

 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Regulation Of Androgen Receptor Activity Pathway antibodies  Regulation Of Androgen Receptor Activity Pathway Diagram

Diseases associated with anti-MYST2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >9 publications with MYST2 and Neoplasms
 Kidney Diseases Antibodies  >2 publications with MYST2 and Kidney Diseases
 Carcinoma Antibodies  >2 publications with MYST2 and Carcinoma
 Renal Insufficiency Antibodies  >1 publications with MYST2 and Renal Insufficiency
 Neurobehavioral Manifestations Antibodies  >1 publications with MYST2 and Neurobehavioral Manifestations
 Brain Diseases Antibodies  >1 publications with MYST2 and Brain Diseases
 Congenital Abnormalities Antibodies  >1 publications with MYST2 and Congenital Abnormalities
 Urinary Bladder Neoplasms Antibodies  >1 publications with MYST2 and Urinary Bladder Neoplasms

Organs/Tissues associated with anti-MYST2 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >3 publications with MYST2 and Kidney
 Testis Antibodies  >3 publications with MYST2 and Testis
 Thyroid Antibodies  >2 publications with MYST2 and Thyroid
 Brain Antibodies  >2 publications with MYST2 and Brain
 Esophagus Antibodies  >1 publications with MYST2 and Esophagus
 Vascular Antibodies  >1 publications with MYST2 and Vascular
 Lung Antibodies  >1 publications with MYST2 and Lung
 Prostate Antibodies  >1 publications with MYST2 and Prostate
 Bladder Antibodies  >1 publications with MYST2 and Bladder
 Embryonic Tissue Antibodies  >1 publications with MYST2 and Embryonic Tissue
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