Rabbit Anti-NACC2 Polyclonal Antibody – Cat# MBS9204777

NACC2 Antibody (C-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the NACC2 antibody detected the NACC2 protein (arrow).

NACC2 Antibody – Rabbit Polyclonal

Name: NACC2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS9204777
Price: 240 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9204777

BTBD14A (BTB/POZ domain-containing protein 14A), also known as BTBD14, is a 587 amino acid protein that contains one BTB/POZ domain. The BTB/POZ domain mediates homomeric and heteromeric POZ-POZ interactions and is common to transcriptional regulators… More details

$240 / 0.08 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NACC2, Polyclonal Antibody

Full Product Name

NACC2 Antibody (C-term)

Product Gene Name

anti-NACC2 antibody

Product Synonym Names

Nucleus accumbens-associated protein 2; NAC-2; BTB/POZ domain-containing protein 14A; Repressor with BTB domain and BEN domain; NACC2; BTBD14A; NAC2; RBB

Clonality

Polyclonal

Isotype

Rabbit Ig

Host

Rabbit

Species Reactivity

Human

Form/Format

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Purity/Purification

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Concentration

Vial Concentration: 0.3 (lot specific)

Specificity

This NACC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 473-502 amino acids from the C-terminal region of human NACC2.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

NACC2 peptide (MBS9221943) is used for blocking the activity of NACC2 antibody (MBS9204777)

Molecular Weight

62837

Immunogen Sequence Positions

473-502

OMIM

615786

3D Structure

ModBase 3D Structure for Q96BF6

Antigen Type

Synthetic Peptide

Antigen Source

HUMAN

Applications Tested/Suitable for anti-NACC2 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-NACC2 antibody

WB~~1:1000

Product References and Citations for anti-NACC2 antibody

Rose, J. Phd, et al. Mol. Med. (2010) In press :
Humphray, S.J., et al. Nature 429(6990):369-374(2004)

Other Notes

Small volumes of anti-NACC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NACC2 purchase

MBS9204777 is an antibody targeting NACC2. Also known as NACC2 Antibody (C-term). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NACC2. It may not necessarily be applicable to this product.

NCBI GI #

21389533

NCBI GeneID

138151

NCBI Accession #

NP_653254.1

UniProt Primary Accession #

Q96BF6

UniProt Related Accession #

Q96BF6

GenBank Nucleotide #

NM_144653.4

NCBI Official Full Name

nucleus accumbens-associated protein 2

NCBI Official Synonym Full Names

NACC family member 2, BEN and BTB (POZ) domain containing

NCBI Official Symbol

NACC2

NCBI Official Synonym Symbols

RBB; BEND9; NAC-2; BTBD14; BTBD31; BTBD14A

UniProt Protein Name

Nucleus accumbens-associated protein 2

UniProt Synonym Protein Names

BTB/POZ domain-containing protein 14A; Repressor with BTB domain and BEN domain

Protein Family

Nucleus accumbens-associated protein

UniProt Gene Name

NACC2

UniProt Synonym Gene Names

BTBD14A; NAC2; RBB; NAC-2

UniProt Entry Name

NACC2_HUMAN

NCBI Protein Information

nucleus accumbens-associated protein 2

UniProt Comments for NACC2

BTBD14A: Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. Homooligomer; mediated by the BTB domain. Interacts with the NuRD complex. Interacts (via C-terminal part) with HDAC2. Interacts (via BTB domain) with MTA1, MTA2 and MTA3

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: nuclear body; nuclear chromatin; NuRD complex; nucleus

Molecular Function: protein binding; protein homodimerization activity; histone deacetylase binding; histone deacetylase activity

Biological Process: transcription from RNA polymerase II promoter; negative regulation of cell proliferation; positive regulation of cell proliferation; histone deacetylation; negative regulation of transcription, DNA-dependent; protein homooligomerization

Research Articles on NACC2

1. RBB is a novel transcriptional repressor and an important regulator of p53 pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.