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NAP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6457503

MBS6457503 is an antibody targeting NAP1. Also known as NAP1 (5-azacytidine-Induced Protein 2, NF-kappa-B-activating Kinase-Associated Protein 1, Nak-Associated Protein 1, TILP, AZI2, NAP1, TBKBP2) (PE). Reactive in Human. Host: Rabbit. More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NAP1, Polyclonal Antibody
Full Product Name
NAP1 (5-azacytidine-Induced Protein 2, NF-kappa-B-activating Kinase-Associated Protein 1, Nak-Associated Protein 1, TILP, AZI2, NAP1, TBKBP2) (PE)
Product Gene Name
anti-NAP1 antibody
Product Synonym Gene Name
AZI2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified
Specificity
Recognizes human NAP1. Species Crossreactivity: human
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
44,935 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (28363845..28390618, complement). Location: 3p24.1
OMIM
609916
3D Structure
ModBase 3D Structure for Q9H6S1
Immunogen
KLH conjugated synthetic peptide corresponding to human NAP1.
Conjugate
PE
Note
Preservative Free

Product Categories/Family for anti-NAP1 antibody

Antibodies; Protein Kinases
Applications Tested/Suitable for anti-NAP1 antibody
Western Blot (WB)
Application Notes for anti-NAP1 antibody
WB: 1:1000
Applications are based on unconjugated antibody.

Product References and Citations for anti-NAP1 antibody

Fujita F., et al. Mol. Cell. Biol. 23:7780-7793(2003). Inohara N., et al. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases. Ota T., et al. Nat. Genet. 36:40-45(2004). Muzny D.M., et al. Nature 440:1194-1198(2006). Mural R.J., et al. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

Other Notes

Small volumes of anti-NAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NAP1. It may not necessarily be applicable to this product.

NCBI GI #
11968003
NCBI GeneID
64343
NCBI Accession #
NP_071906.1
UniProt Primary Accession #
Q9H6S1
UniProt Secondary Accession #
Q86W99; Q9BQF1; A8K3M2
UniProt Related Accession #
Q9H6S1
GenBank Nucleotide #
NM_022461.4
NCBI Official Full Name
5-azacytidine-induced protein 2 isoform a
NCBI Official Synonym Full Names
5-azacytidine induced 2
NCBI Official Symbol
AZI2
NCBI Official Synonym Symbols
AZ2; NAP1; TILP
UniProt Protein Name
5-azacytidine-induced protein 2
UniProt Synonym Protein Names
NF-kappa-B-activating kinase-associated protein 1; Nak-associated protein 1; TILP
Protein Family
Napin
UniProt Gene Name
AZI2
UniProt Synonym Gene Names
NAP1; Nak-associated protein 1
UniProt Entry Name
AZI2_HUMAN
NCBI Protein Information
5-azacytidine-induced protein 2; NAK-associated protein 1; 5-azacytidine induced gene 2; NF-kappa-B-activating kinase-associated protein 1

NCBI Summary for NAP1

AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008]

UniProt Comments for NAP1

AZI2: Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFN-beta promoter activation via TICAM1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 3p24.1

Cellular Component: cytoplasm

Molecular Function: protein binding

Biological Process: tumor necrosis factor production; I-kappaB kinase/NF-kappaB cascade; T cell activation; interleukin-6 production; interferon-gamma production; mitotic cell cycle; interferon-alpha production
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Research Articles on NAP1

1. the spatiotemporal mobilization of TICAM-1 in response to dsRNA and the formation of the TICAM-1 speckles containing RIP1 and NAP1 are important for the activation of the TLR3-TICAM-1 pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NAP1 antibody

 Reference Product  PubMed Publications
 TBK1 antibody  >2 publications with NAP1 and TBK1
 IKBKE antibody  >1 publications with NAP1 and IKBKE

Pathways associated with anti-NAP1 antibody

 Products by Pathway  Pathway Diagram
 RIG-I-like Receptor Signaling Pathway antibodies  RIG-I-like Receptor Signaling Pathway Diagram
 RIG-I-like Receptor Signaling Pathway antibodies  RIG-I-like Receptor Signaling Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram

Organs/Tissues associated with anti-NAP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with NAP1 and Bone
 Heart Antibodies  >1 publications with NAP1 and Heart
 Bone Marrow Antibodies  >1 publications with NAP1 and Bone Marrow
 Muscle Antibodies  >1 publications with NAP1 and Muscle
 Embryonic Tissue Antibodies  >1 publications with NAP1 and Embryonic Tissue
 Brain Antibodies  >1 publications with NAP1 and Brain
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