Natriuretic Peptide Precursor B (NPPB) Antibody – Rabbit Polyclonal

This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]

NPPB: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family.

Protein type: Hormone; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: extracellular region; extracellular space; nucleus; perinuclear region of cytoplasm; protein complex

Molecular Function: diuretic hormone activity; hormone activity; peptide hormone receptor binding; protein binding; receptor binding

Biological Process: body fluid secretion; cell surface receptor signaling pathway; cGMP biosynthetic process; inflammatory response; negative regulation of angiogenesis; negative regulation of cell growth; negative regulation of smooth muscle cell proliferation; negative regulation of systemic arterial blood pressure; protein folding; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; regulation of vascular permeability; response to calcium ion; response to drug; response to hypoxia; response to lipopolysaccharide; response to organic cyclic compound; response to peptide hormone