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NDST4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6324327

Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NDST4, Polyclonal Antibody
Full Product Name
NDST4, NT (NDST4, HSST4, Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4, Glucosaminyl N-deacetylase/N-sulfotransferase 4, N-heparan sulfate sulfotransferase 4, Heparan sulfate N-deacetylase 4, Heparan sulfate N-sulfotransferase 4) (MaxLig
Product Gene Name
anti-NDST4 antibody
Product Synonym Names
NDST4; HSST4; Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4; Glucosaminyl N-deacetylase/N-sulfotransferase 4; N-heparan sulfate sulfotransferase 4; Heparan sulfate N-deacetylase 4; Heparan sulfate N-sulfotransferase 4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
100,716 Da
OMIM
615039
3D Structure
ModBase 3D Structure for Q9H3R1
Immunogen
NDST4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 184-212 amino acids from the N-terminal region of human NDST4.
Conjugate
MaxLight550
Note
Preservative Free

Product Categories/Family for anti-NDST4 antibody

Antibodies; Enzymes; Sulfotransferase
Applications Tested/Suitable for anti-NDST4 antibody
Western Blot (WB), FLISA
Application Notes for anti-NDST4 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-NDST4 antibody

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010). Treutlein, J., et al. Arch. Gen. Psychiatry 66(7):773-784(2009). Aikawa, J., et al. J. Biol. Chem. 276(8):5876-5882(2001).

Other Notes

Small volumes of anti-NDST4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NDST4 purchase

MBS6324327 is an antibody targeting NDST4. Also known as NDST4, NT (NDST4, HSST4, Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4, Glucosaminyl N-deacetylase/N-sulfotransferase 4, N-heparan sulfate sulfotransferase 4, Heparan sulfate N-deacetylase 4, Heparan sulfate N-sulfotransferase 4) (MaxLig. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NDST4. It may not necessarily be applicable to this product.

NCBI GI #
12007650
NCBI GeneID
64579
NCBI Accession #
NP_072091.1
UniProt Primary Accession #
Q9H3R1
UniProt Related Accession #
Q9H3R1
GenBank Nucleotide #
NM_022569.1
NCBI Official Full Name
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4
NCBI Official Synonym Full Names
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
NCBI Official Symbol
NDST4
NCBI Official Synonym Symbols
NDST-4; NHSST4
UniProt Protein Name
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4
UniProt Synonym Protein Names
Glucosaminyl N-deacetylase/N-sulfotransferase 4; NDST-4; N-heparan sulfate sulfotransferase 4
Protein Family
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase
UniProt Gene Name
NDST4
UniProt Synonym Gene Names
HSST4; NDST-4; N-HSST 4
UniProt Entry Name
NDST4_HUMAN
NCBI Protein Information
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferase 4

UniProt Comments for NDST4

NDST4: Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity. Belongs to the sulfotransferase 1 family. NDST subfamily.

Protein type: EC 2.8.2.8; Glycan Metabolism - heparan sulfate biosynthesis; Hydrolase; Transferase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q26

Cellular Component: Golgi membrane; integral to membrane

Molecular Function: deacetylase activity; [heparan sulfate]-glucosamine N-sulfotransferase activity

Biological Process: heparin biosynthetic process; heparan sulfate proteoglycan biosynthetic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-NDST4 antibody

 Products by Pathway  Pathway Diagram
 Glycosaminoglycan Biosynthesis - Heparan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Heparan Sulfate Pathway Diagram
 Glycosaminoglycan Biosynthesis - Heparan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Heparan Sulfate Pathway Diagram
 Glycosaminoglycan Biosynthesis, Heparan Sulfate Backbone Pathway antibodies  Glycosaminoglycan Biosynthesis, Heparan Sulfate Backbone Pathway Diagram
 Glycosaminoglycan Biosynthesis, Heparan Sulfate Backbone Pathway antibodies  Glycosaminoglycan Biosynthesis, Heparan Sulfate Backbone Pathway Diagram
 Heparan Sulfate Biosynthesis Pathway antibodies  Heparan Sulfate Biosynthesis Pathway Diagram
 Heparan Sulfate Biosynthesis Pathway antibodies  Heparan Sulfate Biosynthesis Pathway Diagram
 Heparan Sulfate Biosynthesis (late Stages) Pathway antibodies  Heparan Sulfate Biosynthesis (late Stages) Pathway Diagram
 Heparan Sulfate Biosynthesis (late Stages) Pathway antibodies  Heparan Sulfate Biosynthesis (late Stages) Pathway Diagram

Organs/Tissues associated with anti-NDST4 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with NDST4 and Lung
 Brain Antibodies  >1 publications with NDST4 and Brain
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