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NDUFAF2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6324401

MBS6324401 is an antibody targeting NDUFAF2. Also known as NDUFAF2, ID (NDUFAF2, NDUFA12L, Mimitin, mitochondrial, B17.2-like, Myc-induced mitochondrial protein, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2, NDUFA12-like protein)… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
NDUFAF2, Polyclonal Antibody
Full Product Name
NDUFAF2, ID (NDUFAF2, NDUFA12L, Mimitin, mitochondrial, B17.2-like, Myc-induced mitochondrial protein, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2, NDUFA12-like protein) (Azide free) (HRP)
Product Gene Name
anti-NDUFAF2 antibody
Product Synonym Names
NDUFAF2; NDUFA12L; Mimitin, mitochondrial; B17.2-like; Myc-induced mitochondrial protein; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2; NDUFA12-like protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human NDUFAF2.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
19,856 Da
OMIM
252010
3D Structure
ModBase 3D Structure for Q8N183
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 71-99 in the central terminal region of human NDUFAF2.
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-NDUFAF2 antibody

Antibodies; Mitochondrial Proteins
Applications Tested/Suitable for anti-NDUFAF2 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA)
Application Notes for anti-NDUFAF2 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-NDUFAF2 antibody

Western Blot analysis in HepG2 cell line lysates (35ug/lane), usingMBS649912. This demonstrates that MBS649912 detected the NDUFAF2 protein (arrow).
Rabbit Anti-NDUFAF2 Polyclonal Antibody – Cat# MBS6324401

Immunohistochemistry (IHC) of anti-NDUFAF2 antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle, using MBS649912 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS649912 for immunohistochemistry.
Rabbit Anti-NDUFAF2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6324401

Product References and Citations for anti-NDUFAF2 antibody

1. Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010). 2. Lesch, K.P., et al. Mol. Psychiatry (2010). 3. Herzer, M., et al. Neuropediatrics 41(1):30-34(2010). 4. Hoefs, S.J., et al. Hum. Mutat. 30 (7), E728-E736 (2009). 5. Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008).

Other Notes

Small volumes of anti-NDUFAF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NDUFAF2. It may not necessarily be applicable to this product.

NCBI GI #
29789409
NCBI GeneID
91942
NCBI Accession #
NP_777549.1
UniProt Primary Accession #
Q8N183
UniProt Secondary Accession #
A8K5I1
UniProt Related Accession #
Q8N183
GenBank Nucleotide #
NM_174889.4
NCBI Official Full Name
mimitin, mitochondrial
NCBI Official Synonym Full Names
NADH dehydrogenase (ubiquinone) complex I, assembly factor 2
NCBI Official Symbol
NDUFAF2
NCBI Official Synonym Symbols
MMTN; B17.2L; mimitin; NDUFA12L
UniProt Protein Name
Mimitin, mitochondrial
UniProt Synonym Protein Names
B17.2-like; B17.2L; Myc-induced mitochondrial protein; MMTN; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2; NDUFA12-like protein
Protein Family
Mimitin
UniProt Gene Name
NDUFAF2
UniProt Synonym Gene Names
NDUFA12L; B17.2L; MMTN
UniProt Entry Name
MIMIT_HUMAN
NCBI Protein Information
mimitin, mitochondrial; Myc-induced mitochondrial protein; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2; NDUFA12-like protein

NCBI Summary for NDUFAF2

NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene cause progressive encephalopathy resulting from mitochondrial complex I deficiency. [provided by RefSeq, Jul 2008]
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UniProt Comments for NDUFAF2

NDUFAF2: Acts as a molecular chaperone for mitochondrial complex I assembly. Defects in NDUFAF2 are a cause of mitochondrial complex I deficiency (MT-C1D). A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. Belongs to the complex I NDUFA12 subunit family.

Chromosomal Location of Human Ortholog: 5q12.1

Cellular Component: mitochondrion

Molecular Function: NADH dehydrogenase (ubiquinone) activity

Disease: Leigh Syndrome; Mitochondrial Complex I Deficiency
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Research Articles on NDUFAF2

1. Within the clinical spectrum of Leigh disease, patients with mutations in NDUFAF2 present with a distinct clinical pattern with predominantly brainstem involvement on MRI

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NDUFAF2 antibody

 Reference Product  PubMed Publications
 NDUFA12 antibody  >3 publications with NDUFAF2 and NDUFA12
 NDUFS4 antibody  >2 publications with NDUFAF2 and NDUFS4
 NDUFAF4 antibody  >1 publications with NDUFAF2 and NDUFAF4
 C20orf7 antibody  >1 publications with NDUFAF2 and C20orf7
 MAP1S antibody  >1 publications with NDUFAF2 and MAP1S
 MYC antibody  >1 publications with NDUFAF2 and MYC

Pathways associated with anti-NDUFAF2 antibody

 Products by Pathway  Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Activation Pathway antibodies  Validated Targets Of C-MYC Transcriptional Activation Pathway Diagram

Diseases associated with anti-NDUFAF2 antibody

 Disease Name  Pubmed Publications
 Leigh Disease Antibodies  >2 publications with NDUFAF2 and Leigh Disease
 Brain Diseases, Metabolic, Inborn Antibodies  >2 publications with NDUFAF2 and Brain Diseases, Metabolic, Inborn
 Genital Diseases, Male Antibodies  >1 publications with NDUFAF2 and Genital Diseases, Male
 Prostatic Diseases Antibodies  >1 publications with NDUFAF2 and Prostatic Diseases
 Congenital Abnormalities Antibodies  >1 publications with NDUFAF2 and Congenital Abnormalities
 Mitochondrial complex I deficiency Antibodies  >1 publications with NDUFAF2 and Mitochondrial complex I deficiency

Organs/Tissues associated with anti-NDUFAF2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with NDUFAF2 and Brain
 Muscle Antibodies  >2 publications with NDUFAF2 and Muscle
 Skin Antibodies  >2 publications with NDUFAF2 and Skin
 Pancreas Antibodies  >1 publications with NDUFAF2 and Pancreas
 Lung Antibodies  >1 publications with NDUFAF2 and Lung
 Liver Antibodies  >1 publications with NDUFAF2 and Liver
 Prostate Antibodies  >1 publications with NDUFAF2 and Prostate
 Heart Antibodies  >1 publications with NDUFAF2 and Heart
 Embryonic Tissue Antibodies  >1 publications with NDUFAF2 and Embryonic Tissue
 Kidney Antibodies  >1 publications with NDUFAF2 and Kidney
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