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NELF Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6324653

The protein encoded by this gene is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
NELF, Polyclonal Antibody
Full Product Name
NELF, CT (NELF, Nasal embryonic luteinizing hormone-releasing hormone factor) (FITC)
Product Gene Name
anti-NELF antibody
Product Synonym Names
NELF; Nasal embryonic luteinizing hormone-releasing hormone factor
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
OMIM
gene 614838
3D Structure
ModBase 3D Structure for Q6X4W1
Immunogen
NELF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 500-530 amino acids from the C-terminal region of human NELF.
Conjugate
FITC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-NELF antibody

Antibodies; Hormones; Steroids
Applications Tested/Suitable for anti-NELF antibody
Western Blot (WB), FLISA
Application Notes for anti-NELF antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-NELF antibody

NELF Antibody (C-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the NELF antibody detected the NELF protein (arrow).
Rabbit Anti-NELF Polyclonal Antibody – Cat# MBS6324653

Product References and Citations for anti-NELF antibody

Xu, N., et al. Mol. Cell. Endocrinol. 319 (1-2), 47-55 (2010): Trarbach, E.B., et al. Clin. Endocrinol. (Oxf) 72(3):371-376(2010). Yung, T.M., et al. Exp. Cell Res. 315(10):1693-1705(2009). Pedersen-White, J.R., et al. Mol. Hum. Reprod. 14(6):367-370(2008). Lim, J., et al. Cell 125(4):801-814(2006).

Other Notes

Small volumes of anti-NELF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NELF purchase

MBS6324653 is an antibody targeting NELF. Also known as NELF, CT (NELF, Nasal embryonic luteinizing hormone-releasing hormone factor) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NELF. It may not necessarily be applicable to this product.

NCBI GI #
195972911
NCBI GeneID
26012
NCBI Accession #
NP_001124442.1
NCBI Related Accession #
NP_001124441.1
UniProt Primary Accession #
Q6X4W1
UniProt Related Accession #
Q6X4W1
GenBank Nucleotide #
NP_001124442.1
NCBI Official Full Name
NMDA receptor synaptonuclear signaling and neuronal migration factor isoform c
NCBI Official Synonym Full Names
NMDA receptor synaptonuclear signaling and neuronal migration factor
NCBI Official Symbol
NSMF
NCBI Official Synonym Symbols
HH9; NELF
UniProt Protein Name
NMDA receptor synaptonuclear signaling and neuronal migration factor
UniProt Synonym Protein Names
Nasal embryonic luteinizing hormone-releasing hormone factor; Nasal embryonic LHRH factor
Protein Family
Negative elongation factor
UniProt Gene Name
NSMF
UniProt Synonym Gene Names
NELF; Nasal embryonic LHRH factor
UniProt Entry Name
NSMF_HUMAN
NCBI Protein Information
NMDA receptor synaptonuclear signaling and neuronal migration factor

UniProt Comments for NELF

NSMF: Couples NMDA receptor signaling to the nucleus. Influences outgrowth of olfactory axons and migration of LHRH neurons. Defects in NELF may be associated with idiopathic hypogonadotropic hypogonadism (IHH). IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: cortical cytoskeleton; nuclear membrane; neuron projection; nuclear matrix; postsynaptic density; dendrite; nuclear envelope; perikaryon; nucleoplasm; postsynaptic membrane; membrane; cytoplasm; synapse; nucleus; cell junction

Molecular Function: calcium-dependent protein binding

Biological Process: regulation of dendrite morphogenesis; regulation of neuron apoptosis; positive regulation of protein amino acid dephosphorylation; regulation of neuronal synaptic plasticity

Disease: Hypogonadotropic Hypogonadism 9 With Or Without Anosmia
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Research Articles on NELF

1. These findings suggest a role for NELF in the regulation of the JAK/STAT signaling pathway, which have important functions in GnRH neurons.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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