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NFE2L2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6490629

MBS6490629 is an antibody targeting NFE2L2. Also known as NFE2L2, NT (NRF2, Nuclear Factor Erythroid 2-related Factor 2, NFE2-related Factor 2, NF-E2-related Factor 2, Nuclear Factor, Erythroid Derived 2, Like 2, HEBP1) (APC). Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NFE2L2, Polyclonal Antibody
Full Product Name
NFE2L2, NT (NRF2, Nuclear Factor Erythroid 2-related Factor 2, NFE2-related Factor 2, NF-E2-related Factor 2, Nuclear Factor, Erythroid Derived 2, Like 2, HEBP1) (APC)
Product Gene Name
anti-NFE2L2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein G Affinity Chromatography.
Specificity
Recognizes human NRF2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
69.9kDa (625aa)
OMIM
600492
3D Structure
ModBase 3D Structure for Q16236
Immunogen
Synthetic peptide selected from the N-terminal region of human NRF2 (KLH).
Conjugate
APC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-NFE2L2 antibody

Antibodies; Transcription Factors
Applications Tested/Suitable for anti-NFE2L2 antibody
Western Blot (WB), FLISA
Application Notes for anti-NFE2L2 antibody
WB: 1:50-1:100
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-NFE2L2 antibody

Western blot analysis of anti-NFE2L2 Antibody (N-term) in Ramos cell line lysates (35ug/lane). Nrf2(arrow) was detected using the purified Pab.
Rabbit Anti-NFE2L2 Polyclonal Antibody – Cat# MBS6490629

Western Blot (WB) of anti-NFE2L2 antibody

Western blot analysis of Nrf2(Nfe2l2)(arrow) using rabbit polyclonal Nrf2(Nfe2l2) Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the Nrf2(Nfe2l2) gene (Lane 2) (Origene Technologies).
Rabbit Anti-NFE2L2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6490629

Product References and Citations for anti-NFE2L2 antibody

1. Zhao, X., Stroke 38(12), 3280-3286 (2007). 2. Li, M.H., J. Biol. Chem. 282(39), 28577-28586 (2007).

Other Notes

Small volumes of anti-NFE2L2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NFE2L2. It may not necessarily be applicable to this product.

NCBI GI #
21361440
NCBI GeneID
5866
NCBI Accession #
NP_006155
UniProt Primary Accession #
Q16236
UniProt Secondary Accession #
Q86V32; Q9P1Q8
UniProt Related Accession #
Q8TBN0
GenBank Nucleotide #
NM_013401.3
NCBI Official Full Name
guanine nucleotide exchange factor for Rab-3A isoform 1
NCBI Official Synonym Full Names
RAB3A interacting protein like 1
NCBI Official Symbol
RAB3IL1
NCBI Official Synonym Symbols
GRAB
UniProt Protein Name
Nuclear factor erythroid 2-related factor 2
UniProt Synonym Protein Names
HEBP1; Nuclear factor, erythroid derived 2, like 2
Protein Family
Nuclear factor erythroid 2-related factor
UniProt Gene Name
NFE2L2
UniProt Synonym Gene Names
NRF2; NF-E2-related factor 2
UniProt Entry Name
NF2L2_HUMAN
NCBI Protein Information
guanine nucleotide exchange factor for Rab-3A

NCBI Summary for NFE2L2

This gene encodes a guanine nucleotide exchange factor for the ras-related protein Rab3A. The encoded protein binds Rab3a and the inositol hexakisphosphate kinase InsP6K1. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2012]
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UniProt Comments for NFE2L2

NRF2: a transcription factor that regulates basal expression and antioxidant induction of a transcription factor for NAD(P)H:quinone oxidoreductase-1 (NQO1) and other detoxifying genes. Targeted for proteasomal degradation by INrf2. Oxidative stress causes its phosphorylation and release from INrf2.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2q31

Cellular Component: nucleoplasm; centrosome; cytoplasm; plasma membrane; nucleus; chromatin; cytosol

Molecular Function: protein domain specific binding; protein binding; DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; positive regulation of blood coagulation; unfolded protein response; regulation of embryonic development; proteasomal ubiquitin-independent protein catabolic process; protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter
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Research Articles on NFE2L2

1. Intermediates in the guanine nucleotide exchange reaction of Rab8 protein catalyzed by guanine nucleotide exchange factors Rabin8 and GRAB.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NFE2L2 antibody

 Reference Product  PubMed Publications
 RAB3A antibody  >2 publications with NFE2L2 and RAB3A
 RAB11A antibody  >1 publications with NFE2L2 and RAB11A
 RAB3IP antibody  >1 publications with NFE2L2 and RAB3IP

Pathways associated with anti-NFE2L2 antibody

 Products by Pathway  Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 RAB GEFs Exchange GTP For GDP On RABs Pathway antibodies  RAB GEFs Exchange GTP For GDP On RABs Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram
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