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NKAP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6325443

This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
NKAP, Polyclonal Antibody
Full Product Name
NKAP, CT (NKAP, NF-kappa-B-activating protein) (PE)
Product Gene Name
anti-NKAP antibody
Product Synonym Names
NKAP; NF-kappa-B-activating protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
47,138 Da
OMIM
300766
3D Structure
ModBase 3D Structure for Q8N5F7
Immunogen
NKAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 394-415 amino acids from the C-terminal region of human NKAP.
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-NKAP antibody

Antibodies; Transcription Factors
Applications Tested/Suitable for anti-NKAP antibody
Western Blot (WB), FLISA
Application Notes for anti-NKAP antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-NKAP antibody

NKAP Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the NKAP antibody detected the NKAP protein (arrow).
Rabbit Anti-NKAP Polyclonal Antibody – Cat# MBS6325443

Product References and Citations for anti-NKAP antibody

D'Addabbo, A., et al. Artif Intell Med 46(2):131-138(2009). Pajerowski, A.G., et al. Immunity 30(5):696-707(2009). Lamesch, P., et al. Genomics 89(3):307-315(2007). Chen, D., et al. Biochem. Biophys. Res. Commun. 310(3):720-724(2003).

Other Notes

Small volumes of anti-NKAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NKAP purchase

MBS6325443 is an antibody targeting NKAP. Also known as NKAP, CT (NKAP, NF-kappa-B-activating protein) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NKAP. It may not necessarily be applicable to this product.

NCBI GI #
168229156
NCBI GeneID
79576
NCBI Accession #
NP_078804.2
UniProt Primary Accession #
Q8N5F7
UniProt Secondary Accession #
Q6IPW6; Q96BQ2; Q9H638
UniProt Related Accession #
Q8N5F7
GenBank Nucleotide #
NM_024528.3
NCBI Official Full Name
NF-kappa-B-activating protein
NCBI Official Synonym Full Names
NFKB activating protein
NCBI Official Symbol
NKAP
UniProt Protein Name
NF-kappa-B-activating protein
Protein Family
NF-kappa-B-activating protein
UniProt Gene Name
NKAP
UniProt Entry Name
NKAP_HUMAN
NCBI Protein Information
NF-kappa-B-activating protein

UniProt Comments for NKAP

NKAP: Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. Belongs to the UPF0396 family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: cytoplasm; nucleoplasm

Molecular Function: chromatin binding; chromatin DNA binding; protein binding

Biological Process: granulocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; Notch signaling pathway; positive regulation of alpha-beta T cell differentiation; stem cell maintenance; T cell differentiation in the thymus; transcription, DNA-dependent
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Research Articles on NKAP

1. NKAP is required for T cell maturation and the acquisition of functional competency

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NKAP antibody

 Reference Product  PubMed Publications
 FUS antibody  >1 publications with NKAP and FUS

Diseases associated with anti-NKAP antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >3 publications with NKAP and Necrosis
 Disease Models, Animal Antibodies  >1 publications with NKAP and Disease Models, Animal
 Liver Diseases Antibodies  >1 publications with NKAP and Liver Diseases
 Inflammation Antibodies  >1 publications with NKAP and Inflammation

Organs/Tissues associated with anti-NKAP antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with NKAP and Blood
 Thymus Antibodies  >3 publications with NKAP and Thymus
 Bone Marrow Antibodies  >2 publications with NKAP and Bone Marrow
 Bone Antibodies  >2 publications with NKAP and Bone
 Liver Antibodies  >1 publications with NKAP and Liver
 Pancreas Antibodies  >1 publications with NKAP and Pancreas
 Eye Antibodies  >1 publications with NKAP and Eye
 Brain Antibodies  >1 publications with NKAP and Brain
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