Mouse Anti-NLGN4X Polyclonal Antibody – Cat# MBS6002576

Western Blot analysis of NLGN4X expression in transfected 293T cell line by NLGN4X polyclonal antibody. Lane 1: NLGN4X transfected lysate (89.76kD). Lane 2: Non-transfected lysate.

NLGN4X Antibody – Mouse Polyclonal

Name: NLGN4X Antibody; Polyclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6002576
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6002576

MBS6002576 is an antibody targeting NLGN4X. Also known as NLGN4X (Neuroligin-4, X-linked, Neuroligin X, HNLX, KIAA1260, NLGN4, UNQ365/PRO701, ASPGX2, AUTSX2, MGC22376). Reactive in Human. Host: Mouse. Putative neuronal cell surface protein involved in… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NLGN4X, Polyclonal Antibody

Full Product Name

NLGN4X (Neuroligin-4, X-linked, Neuroligin X, HNLX, KIAA1260, NLGN4, UNQ365/PRO701, ASPGX2, AUTSX2, MGC22376)

Product Gene Name

anti-NLGN4X antibody

Product Synonym Names

Anti -NLGN4X (Neuroligin-4, X-linked, Neuroligin X, HNLX, KIAA1260, NLGN4, UNQ365/PRO701, ASPGX2, AUTSX2, MGC22376)

Immunogen Sequence

MSRPQGLLWL PLLFTPVCVM LNSNVLLWLT ALAIKFTLID SQAQYPVVNT NYGKIRGLRT PLPNEILGPV EQYLGVPYAS PPTGERRFQP PEPPSSWTGI RNTTQFAAVC PQHLDERSLL HDMLPIWFTA NLDTLMTYVQ DQNEDCLYLN IYVPTEDDIH DQNSKKPVMV YIHGGSYMEG TGNMIDGSIL ASYGNVIVIT INYRLGILGF LSTGDQAAKG NYGLLDQIQA LRWIEENVGA FGGDPKRVTI FGSGAGASCV SLLTLSHYSE GLFQKAIIQS GTALSSWAVN YQPAKYTRIL ADKVGCNMLD TTDMVECLRN KNYKELIQQT ITPATYHIAF GPVIDGDVIP DDPQILMEQG EFLNYDIMLG VNQGEGLKFV DGIVDNEDGV TPNDFDFSVS NFVDNLYGYP EGKDTLRETI KFMYTDWADK ENPETRRKTL VALFTDHQWV APAVATADLH AQYGSPTYFY AFYHHCQSEM KPSWADSAHG DEVPYVFGIP MIGPTELFSC NFSKNDVMLS AVVMTYWTNF AKTGDPNQPV PQDTKFIHTK PNRFEEVAWS KYNPKDQLYL HIGLKPRVRD HYRATKVAFW LELVPHLHNL NEIFQYVSTT TKVPPPDMTS FPYGTRRSPA KIWPTTKRPA ITPANNPKHS KDPHKTGPED TTVLIETKRD YSTELSVTIA VGASLLFLNI LAFAALYYKK DKRRHETHRR PSPQRNTTND IAHIQNEEIM SLQMKQLEHD HECESLQAHD TLRLTCPPDY TLTLRRSPDD IPLMTPNTIT MIPNTLTGMQ PLHTFNTFSG GQNSTNLPHG HSTTRV

Clonality

Polyclonal

Isotype

IgG

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human NLGN4X.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

91,915 Da

Chromosome Location

Chromosome: X; NC_000023.10 (5808067..6146916, complement). Location: Xp22.33

OMIM

300427

3D Structure

ModBase 3D Structure for Q8N0W4

Immunogen

Full length human NLGN4X, aa1-816 (NP_065793.1).

Product Categories/Family for anti-NLGN4X antibody

Antibodies; Abs to Neuroligins

Applications Tested/Suitable for anti-NLGN4X antibody

Western Blot (WB)

Application Notes for anti-NLGN4X antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-NLGN4X antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NLGN4X. It may not necessarily be applicable to this product.

NCBI GI #

31076821

NCBI GeneID

57502

NCBI Accession #

Q8N0W4.1

UniProt Primary Accession #

Q8N0W4

UniProt Secondary Accession #

Q6UX10; Q9ULG0

UniProt Related Accession #

Q8N0W4

NCBI Official Full Name

Neuroligin-4, X-linked

NCBI Official Synonym Full Names

neuroligin 4, X-linked

NCBI Official Symbol

NLGN4X

NCBI Official Synonym Symbols

HLNX; HNL4X; NLGN4; ASPGX2; AUTSX2

UniProt Protein Name

Neuroligin-4, X-linked

UniProt Synonym Protein Names

HNLX

Protein Family

Neuroligin

UniProt Gene Name

NLGN4X

UniProt Synonym Gene Names

KIAA1260; NLGN4; Neuroligin X

UniProt Entry Name

NLGNX_HUMAN

NCBI Protein Information

neuroligin-4, X-linked

NCBI Summary for NLGN4X

This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

UniProt Comments for NLGN4X

NLGN4X: Putative neuronal cell surface protein involved in cell- cell-interactions. Defects in NLGN4X may be the cause of susceptibility to autism X-linked type 2 (AUTSX2). AUTSX2 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Defects in NLGN4X may be the cause of susceptibility to X-linked Asperger syndrome 2 (ASPGX2). ASPGX2 is considered to be a form of childhood autism. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22.33

Cellular Component: postsynaptic membrane; extracellular space; cell surface; integral to plasma membrane; postsynaptic density; dendrite; integral to membrane; plasma membrane; excitatory synapse; synapse; cell junction

Molecular Function: protein binding; protein homodimerization activity; neurexin binding; cell adhesion molecule binding; receptor activity; chloride ion binding

Biological Process: regulation of synaptic transmission; neuron differentiation; organ growth; intercellular junction assembly and maintenance; metabolic process; adult behavior; synapse organization and biogenesis; cerebellum development; neuron adhesion; social behavior; learning

Disease: Asperger Syndrome, X-linked, Susceptibility To, 2; Autism, Susceptibility To, X-linked 2

Research Articles on NLGN4X

1. Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NLGN4X antibody

Reference Product	PubMed Publications
NRXN1 antibody	>3 publications with NLGN4X and NRXN1
SHANK3 antibody	>3 publications with NLGN4X and SHANK3
SHANK2 antibody	>1 publications with NLGN4X and SHANK2
DLG4 antibody	>1 publications with NLGN4X and DLG4

Pathways associated with anti-NLGN4X antibody

Products by Pathway	Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram

Diseases associated with anti-NLGN4X antibody

Disease Name	Pubmed Publications
Mental Disorders Antibodies	>41 publications with NLGN4X and Mental Disorders
Child Development Disorders, Pervasive Antibodies	>34 publications with NLGN4X and Child Development Disorders, Pervasive
Autistic Disorder Antibodies	>33 publications with NLGN4X and Autistic Disorder
Gonadal Dysgenesis Antibodies	>1 publications with NLGN4X and Gonadal Dysgenesis

Organs/Tissues associated with anti-NLGN4X antibody

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>27 publications with NLGN4X and Nerve
Brain Antibodies	>19 publications with NLGN4X and Brain
Muscle Antibodies	>3 publications with NLGN4X and Muscle
Blood Antibodies	>2 publications with NLGN4X and Blood
Pancreas Antibodies	>2 publications with NLGN4X and Pancreas
Embryonic Tissue Antibodies	>2 publications with NLGN4X and Embryonic Tissue
Skin Antibodies	>1 publications with NLGN4X and Skin
Heart Antibodies	>1 publications with NLGN4X and Heart
Liver Antibodies	>1 publications with NLGN4X and Liver