Rabbit Anti-NLRP6 Polyclonal Antibody – Cat# MBS6325800

NLRP6Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the NLRP6 antibody detected the NLRP6 protein (arrow).

NLRP6 Antibody – Rabbit Polyclonal

Name: NLRP6 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6325800
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6325800

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NLRP6, Polyclonal Antibody

Full Product Name

NLRP6, NT (NLRP6, NALP6, PYPAF5, NACHT, LRR and PYD domains-containing protein 6, Angiotensin II/vasopressin receptor, PYRIN-containing APAF1-like protein 5) (Azide free) (HRP)

Product Gene Name

anti-NLRP6 antibody

Product Synonym Names

NLRP6; NALP6; PYPAF5; NACHT; LRR and PYD domains-containing protein 6; Angiotensin II/vasopressin receptor; PYRIN-containing APAF1-like protein 5

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

98,768 Da

Chromosome Location

Chromosome: 11; NC_000011.9 (278570..285304). Location: 11p15

OMIM

609650

3D Structure

ModBase 3D Structure for P59044

Immunogen

NLRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-197 amino acids from the N-terminal region of human NLRP6.

Conjugate

HRP

Note

Preservative Free

Product Categories/Family for anti-NLRP6 antibody

Antibodies; Inflammasomes

Applications Tested/Suitable for anti-NLRP6 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-NLRP6 antibody

WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-NLRP6 antibody

Cummings, J.R., et al. Tissue Antigens 76(1):48-56(2010). Davila, S., et al. Genes Immun. 11(3):232-238(2010). Albrecht, M., et al. FEBS Lett. 538 (1-3), 173-177 (2003): Tschopp, J., et al. Nat. Rev. Mol. Cell Biol. 4(2):95-104(2003). Grenier, J.M., et al. FEBS Lett. 530 (1-3), 73-78 (2002).

Other Notes

Small volumes of anti-NLRP6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NLRP6 purchase

MBS6325800 is an antibody targeting NLRP6. Also known as NLRP6, NT (NLRP6, NALP6, PYPAF5, NACHT, LRR and PYD domains-containing protein 6, Angiotensin II/vasopressin receptor, PYRIN-containing APAF1-like protein 5) (Azide free) (HRP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NLRP6. It may not necessarily be applicable to this product.

NCBI GI #

21264320

NCBI GeneID

171389

NCBI Accession #

NP_612202.1

UniProt Primary Accession #

P59044

UniProt Secondary Accession #

A8K9F3

UniProt Related Accession #

P59044

GenBank Nucleotide #

NM_138329.1

NCBI Official Full Name

NACHT, LRR and PYD domains-containing protein 6

NCBI Official Synonym Full Names

NLR family, pyrin domain containing 6

NCBI Official Symbol

NLRP6

NCBI Official Synonym Symbols

PAN3; NALP6; PYPAF5; CLR11.4

UniProt Protein Name

NACHT, LRR and PYD domains-containing protein 6

UniProt Synonym Protein Names

Angiotensin II/vasopressin receptor; PYRIN-containing APAF1-like protein 5

Protein Family

NACHT, LRR and PYD domains-containing protein

UniProt Gene Name

NLRP6

UniProt Synonym Gene Names

NALP6; PYPAF5

UniProt Entry Name

NALP6_HUMAN

NCBI Protein Information

NACHT, LRR and PYD domains-containing protein 6; angiotensin II/vasopressin receptor; PYRIN-containing APAF1-like protein 5; NACHT, LRR and PYD containing protein 6; NACHT, leucine rich repeat and PYD containing 6; nucleotide-binding oligomerization domai

UniProt Comments for NLRP6

NLRP6: May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation. Belongs to the NLRP family.

Protein type: Receptor, misc.

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: nuclear membrane; cytoplasm; plasma membrane

Molecular Function: ATP binding; vasopressin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; wound healing; response to bacterium; negative regulation of MAPKKK cascade; regulation of inflammatory response; negative regulation of immune response; negative regulation of toll-like receptor signaling pathway; regulation of autophagy; negative regulation of I-kappaB kinase/NF-kappaB cascade

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NLRP6 antibody

Reference Product	PubMed Publications
CASP1 antibody	>19 publications with NLRP6 and CASP1
AIM2 antibody	>10 publications with NLRP6 and AIM2
PYCARD antibody	>3 publications with NLRP6 and PYCARD

Diseases associated with anti-NLRP6 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>23 publications with NLRP6 and Inflammation
Disease Models, Animal Antibodies	>4 publications with NLRP6 and Disease Models, Animal
Cardiovascular Diseases Antibodies	>3 publications with NLRP6 and Cardiovascular Diseases
Hypertension Antibodies	>2 publications with NLRP6 and Hypertension
Liver Diseases Antibodies	>2 publications with NLRP6 and Liver Diseases
Brain Diseases Antibodies	>2 publications with NLRP6 and Brain Diseases
Necrosis Antibodies	>2 publications with NLRP6 and Necrosis
Fatty Liver, Alcoholic Antibodies	>1 publications with NLRP6 and Fatty Liver, Alcoholic
Heart Failure Antibodies	>1 publications with NLRP6 and Heart Failure
Liver Cirrhosis Antibodies	>1 publications with NLRP6 and Liver Cirrhosis

Organs/Tissues associated with anti-NLRP6 antibody

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>13 publications with NLRP6 and Intestine
Blood Antibodies	>7 publications with NLRP6 and Blood
Testis Antibodies	>1 publications with NLRP6 and Testis
Kidney Antibodies	>1 publications with NLRP6 and Kidney