NMUR2 Antibody – Rabbit Polyclonal

This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]

NMUR2: Receptor for the neuromedin-U and neuromedin-S neuropeptides. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; GTP binding; intracellular calcium activated chloride channel activity; neuromedin U receptor activity; neuromedin U binding

Biological Process: grooming behavior; regulation of smooth muscle contraction; inositol phosphate-mediated signaling; central nervous system development; calcium-mediated signaling; chloride transport; response to pain; arachidonic acid secretion; reduction of food intake in response to dietary excess; elevation of cytosolic calcium ion concentration; cell-cell signaling; neuropeptide signaling pathway; calcium ion transport; calcium-dependent phospholipase A2 activation; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); feeding behavior